ArticleArtificial organs2020
The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model.
Article in Artificial organs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Perfusate Composition and Duration ofTransplant international : official journal of the European Society for Organ Transplantation · 2022Pooled it
- Spermine: A Hemoglobin Modifier That Reduces Autoxidation and Regulates Oxygen Delivery.International journal of molecular sciences · 2026Article
- Preservation of circulatory death donor Rat hearts using hemoglobin-based oxygen carriers for normothermic machine perfusion: enhancing viability and functionality.Frontiers in cardiovascular medicine · 2026Article
- Barriers and Opportunities to Increase Utilization of Donor Kidneys After Death Determined by Circulatory Criteria Among Children and Adults: A Narrative Review.Canadian journal of kidney health and disease · 2025Review
- VCA supercooling in a swine partial hindlimb model.Scientific reports · 2024Article
- Real-time monitoring of mitochondrial oxygenation during machine perfusion using resonance Raman spectroscopy predicts organ function.Scientific reports · 2024Article
- Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Structural optimization and prospect of constructing hemoglobin oxygen carriers based on hemoglobin.Heliyon · 2023Review
- Multiorgan recovery in a cadaver body using mild hypothermic ECMO treatment in a murine model.Intensive care medicine experimental · 2023Article
- The artificial oxygen carrier erythrocruorin-characteristics and potential significance in medicine.Journal of molecular medicine (Berlin, Germany) · 2023Review
- The Optimization of Renal Graft Preservation Temperature to Mitigate Cold Ischemia-Reperfusion Injury in Kidney Transplantation.International journal of molecular sciences · 2022Review
- External pressure dynamics promote kidney viability and perfusate filtration during ex vivo kidney perfusion.Scientific reports · 2022Article
- HBOC-301 in Porcine Kidney Normothermic Machine Perfusion and the Effect of Vitamin C on Methemoglobin Formation.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Recent Methods of Kidney Storage and Therapeutic Possibilities of Transplant Kidney.Biomedicines · 2022Review
- Article
- Optimal Temperature Protocols for Liver Machine Perfusion Using a Monte Carlo Method.IFAC-PapersOnLine · 2022Article
- Dynamic regulation of anti-oxidation following donation repairing after circulatory determined death renal transplantation with prolonged non-heart-beating time.Journal of biomedical research · 2021Article
- Therapeutic Potential of Hemoglobin Derived from the Marine WormMarine drugs · 2021Review
- New Applications of HBOC-201: A 25-Year Review of the Literature.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Gradual rewarming from hypothermic to normothermic is a novel perfusion modality with superior outcome to sudden rewarming to normothermic. However, the identification of an oxygen carrier that could function at a temperature range from 4 to 7°C or whether it is necessary to use oxygen carrier during kidney rewarming, remains unresolved. This study was designed to test the use of a hemoglobin-based oxygen carrier (HBOC) during gradual kidney rewarming as an alternative to simple dissolved oxygen. In this study, 10 rat kidneys were randomly divided into the control and the HBOC group. In the control group, no oxygen carrier was used during rewarming perfusion and the perfusion solution was oxygenated only by applying diffused carbogen flow. The protocol mimicked a donor after circulatory death (DCD) kidney transplantation, where after 30 minutes warm ischemia and 120 minutes cold storage in University of Wisconsin solution, the DCD kidneys underwent gradual rewarming from 10 to 37°C during 90 minutes with or without HBOC. This was followed by 30 minutes of warm ischemia in room temperature to mimic the anastomosis time and 120 minutes of reperfusion at 37°C to mimic the early post-transplant state of the graft. The HBOC group demonstrated superior kidney function which was highlighted by higher ultrafiltrate production, better glomerular filtration rate and improved sodium reabsorption. There was no significant difference between the 2 groups regarding the hemodynamics, tissue injury, and adenosine triphosphate levels. In conclusion, this study suggests better renal function recovery in DCD kidneys after rewarming with HBOC compared to rewarming without an oxygen carrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.