Evidence map›Paper›PMID 31368118›Full record

ArticleEpilepsia2019

Cortical activation in generalized seizures.

Li Ding, Sanjana Satish, Chengwen Zhou, Martin J Gallagher

Open access · bronzeAbstract read
In one paragraph

Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Network connectivity in primary generalized tonic-clonic seizures.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. TheJournal of clinical medicine · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Li DingDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Sanjana SatishDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Chengwen ZhouDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.
Martin J GallagherDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-3537-4200
Vanderbilt University Medical Center · US

Funding

Subcortical Nodes Within Epileptic Network Control the Cortical Disfacilitation to Prompt Seizure Onset in IGE Mouse ModelR01NS107424 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHOU, CHENGWEN · 2018 to 2022
$2.0M
Impaired homeostatic potentiation of GABAergic currents initiates seizuresR21NS096483 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GALLAGHER, MARTIN J, MACDONALD, ROBERT LOUDEN · 2016 to 2017
$435k
NINDS NIH HHS R01 NS107424NINDS NIH HHS R21 NS096483
6 · The paper itself

Abstract

objectivePatients with generalized epilepsy exhibit different epileptiform events including asymptomatic interictal spikes (IS), absence seizures with spike-wave discharges (SWDs), and myoclonic seizures (MS). Our objective was to determine the spatiotemporal patterns of cortical activation in SWDs, IS, and MS in the Gabra1

methodsWe fabricated affordable, flexible high-density electroencephalography (HdEEG) arrays and recorded spontaneous SWD, IS, and MS with video/HdEEG. We determined differences among the events in amplitude spectral density (ASD) in the δ/θ/α/β/γ frequency bands at baseline (3.5-4.0 seconds before the first spike time, t

resultsAll three events had an increase in ASD between baseline and prespike in at least one frequency band. During prespike, MS had the largest δ-band ASD, but SWD had the greatest α/β/γ band ASD. For all three events, the ASD was largest in the anterior regions. The t SIGNIFICANCE: Changes in spectral density from baseline to prespike indicate that none of these generalized events are instantaneous or entirely unpredictable. Prominent engagement of anterior cortical regions during prespike and at t

Indexed as

Action PotentialsAnimalsCerebral CortexDisease Models, AnimalElectroencephalographyEpilepsy, GeneralizedMiceMice, TransgenicMyoclonic Epilepsy, JuvenileReceptors, GABA-AGabra1 protein, mouseReceptors, GABA-AelectroencephalogramGABAA receptorgeneralizedsignal analysis

Identifiers

PMID31368118
PMCPMC6732052
OpenAlexW2964698367

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.