ArticleAnnals of surgical oncology2019
Facility Type is Associated with Margin Status and Overall Survival of Patients with Resected Intrahepatic Cholangiocarcinoma.
Article in Annals of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Volume-outcome relationship in anatomical and non-anatomical liver resections: a rapid systematic review.BMC gastroenterology · 2026Pooled it
- Social and Surgical Drivers of Survival in Colorectal Liver Metastases: An NCBD Analysis.Journal of surgical oncology · 2026Article
- Effect of Case Discussion with Expert Centers on Treatment Outcome of Intrahepatic Cholangiocarcinoma.Annals of surgical oncology · 2026Article
- HERV2365 upregulates FGF1 expression by sponging miR-326 to promote the progression of intrahepatic cholangiocarcinoma.iScience · 2026Article
- Multi-institutional care is associated with improved survival in biliary tract cancer.Journal of gastrointestinal oncology · 2026Article
- Facility Type Predicts Completeness of Oncologic Resection and Survival in Biliary Tract Cancers.Journal of gastrointestinal cancer · 2026Article
- Pituitary adenoma management and outcomes according to hospital case volume and facility type.World journal of otorhinolaryngology - head and neck surgery · 2025Article
- The impact of facility type on surgical outcomes in colon cancer patients: analysis of the national cancer database.Surgical endoscopy · 2024Article
- Impact of Adjuvant Radiotherapy Setting on Quality-of-Life in Head and Neck Squamous Cell Carcinoma.The Laryngoscope · 2024Observational
- Defining Facility Volume Threshold for Optimization of Short- and Long-Term Outcomes in Patients Undergoing Resection of Perihilar Cholangiocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- Surgical Aspects of Intrahepatic Cholangiocarcinoma.Cancers · 2022Review
- Review
- Primary Site and Other Prognostic Factors for Fibrosarcoma: An Analysis of the National Cancer Database.Cureus · 2021Article
- Liver Resection for Intrahepatic Cholangiocarcinoma-Single-Center Experience with 286 Patients Undergoing Surgical Exploration over a Thirteen Year Period.Journal of clinical medicine · 2021Article
- Patient Comorbidities Drive High Mortality Rates Associated with Major Liver Resections Irrespective of Hospital Volume.The American surgeon · 2021Article
- The impact of treatment facility type on the survival of brain metastases patients regardless of the primary cancer type.BMC cancer · 2021Article
- Surgical management of biliary malignancy.Current problems in surgery · 2021Article
- Surgical Treatment of Intrahepatic Cholangiocarcinoma: Current and Emerging Principles.Journal of clinical medicine · 2020Review
- Cholangiocarcinoma as an Indication for Liver Transplantation in the Era of Transplant Oncology.Journal of clinical medicine · 2020Review
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9 authors.
Funding
Abstract
backgroundMany studies have demonstrated associations between surgical resections at academic centers and improved outcomes, particularly for complex operations. However, few studies have examined this relationship in intrahepatic cholangiocarcinoma (ICC). The hypothesis of this study was that facility type is associated with improved postoperative outcomes and survival for patients with ICC who undergo resection.
methodsPatients with stages 1 to 3 ICC who underwent hepatectomy were identified using the National Cancer Database (NCDB) (2004-2014). Facilities were categorized as academic or community centers per Commission on Cancer designations. High-volume hospitals were those that performed 11 or more hepatectomies per year. Multilevel logistic mixed-effects models to identify predictors of outcomes and parametric survival-time models were used to determine overall survival (OS).
resultsThe study identified 2256 patients. Of these patients, 423 (18.8%) were treated at community centers, and 1833 (81.3%) were treated at academic centers. Nearly all high-volume centers were academic facilities (98.5% academic vs. 1.5% community centers), whereas low-volume centers were mixed (65.5% academic vs. 34.5% community centers) (p < 0.001). Surgery performed at an academic center was an independent predictor of decreased positive margins (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.51-0.98; p = 0.04), a lower 90-day mortality rate (OR, 0.62; 95% CI, 0.39-0.97; p = 0.03), and improved OS (hazard ratio [HR], 0.78; 95% CI, 0.63-0.96; p = 0.02). Facility hepatectomy volume was not independently associated with any short- or long-term outcomes.
conclusionsTreatment at an academic center is associated with fewer positive resection margins, a decreased 90-day mortality rate, and improved OS for patients who undergo ICC resection. Facility surgical volume was not shown to be significantly associated with any postoperative outcomes after adjustment for patient and disease characteristics.
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