Evidence map›Paper›PMID 31367975›Full record

ReviewIndian journal of pediatrics2019

CRISPR-Cas9 Probing of Infectious Diseases and Genetic Disorders.

Sivaprakash Ramalingam, Saravanabhavan Thangavel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Indian journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sivaprakash RamalingamCSIR Institute for Genomics and Integrative Biology (IGIB), Mathura Road, Sukhdev Vihar, New Delhi, India. sivaramalingam@igib.res.in.
Saravanabhavan ThangavelCenter for Stem Cell Research (CSCR), A Unit of inStem Bengaluru, Christian Medical College Campus, Vellore, Tamil Nadu, India. sthangavel@cmcvellore.ac.in.
Institute for Stem Cell Biology and Regenerative Medicine · INInstitute of Genomics and Integrative Biology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to precisely change the deoxyribonucleic acid (DNA) bases at specific sites offers tremendous advantages in the field of molecular biology and medical biotechnology. Identification of Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), revelation of its role in prokaryotic adaptive immunity and subsequent conversion into genome and epigenome engineering system are the landmark research progresses of the decade. The possibilities of deciphering the molecular mechanisms of the disease, identifying the disease targets, generating the disease models, validating the drug targets, developing resistance to the infection and correcting the genotype have brought off much enthusiasm in the field of infectious diseases and genetic disorders. This review focuses on CRISPR/Cas9's impact in the field of infection and genetic disorders.

Indexed as

CRISPR-Cas SystemsClustered Regularly Interspaced Short Palindromic RepeatsCommunicable DiseasesGene EditingGene TargetingGenetic Diseases, InbornGenetic EngineeringGenetic TherapyHumansClustered Regularly-Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated systems (Cas9)Infectious diseases and genetic disordersTargeted genome engineering/editingTranscription activator-like effector nucleasesZinc finger nucleases

Identifiers

PMID31367975
OpenAlexW2966158878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.