Evidence map›Paper›PMID 31367882›Full record

ArticleDigestive diseases and sciences2020

Interval Colorectal Cancer in Inflammatory Bowel Disease: The Role of Guideline Adherence.

Kristin E Burke, Jennifer Nayor, Emily J Campbell, Ashwin N Ananthakrishnan, Hamed Khalili, James M Richter

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kristin E BurkeDivision of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA. KEBURKE@mgh.harvard.edu.
Jennifer NayorDivision of Gastroenterology, Brigham and Women's Hospital, Boston, MA, USA.
Emily J CampbellDepartment of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Ashwin N AnanthakrishnanDivision of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Hamed KhaliliDivision of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
James M RichterDivision of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114, USA.
Massachusetts General Hospital · USBrigham and Women's Hospital · USHarvard University · US

Funding

Oral Contraceptives in the Etiopathogenesis of Crohn's DiseaseK23DK099681 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KHALILI, HAMED · 2013 to 2017
$946k
Genetic and Clinical Predictors of Response to Anti-Tumor Necrosis Factor Therapy in Patients with Ulcerative ColitisF32DK115134 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BURKE, KRISTIN E. · 2018 to 2019
$149k
NIDDK NIH HHS F32 DK115134NIDDK NIH HHS K23 DK099681
6 · The paper itself

Abstract

backgroundFactors associated with interval colorectal cancer (CRC) development in the inflammatory bowel disease (IBD) population remain unclear.

aimsAmong a cohort of patients with interval CRC, we aimed to evaluate IBD characteristics, colonoscopy quality indicators, and surveillance guideline adherence.

methodsWe performed a retrospective review of IBD- and non-IBD-associated interval CRCs diagnosed between January 2007 and December 2014 within a large US healthcare system. We evaluated risk factors for CRC among patients with IBD. We assessed adherence to surveillance guidelines according to the American Society for Gastrointestinal Endoscopy (IBD surveillance) and the US Multi-Society Task Force on Colorectal Cancer (polyp surveillance). We compared colonoscopy quality measures between patients with and without IBD.

resultsAmong 5345 cases of colonic adenocarcinoma, we detected 15 IBD-associated cases of interval CRC and 230 non-IBD-associated cases of interval CRC. Compared to patients without IBD, IBD patients were younger (54.5 vs. 70.4 years; p < 0.0001) and experienced a shorter interval between index colonoscopy and CRC diagnosis (20.7 vs. 35.1 months; p = 0.0009). Fifty three percent (8/15) of interval CRCs in IBD patients were detected within surveillance guidelines. All IBD patients with interval CRC detected after guideline surveillance interval had high-risk features, including active inflammation, previous low-grade or indefinite dysplasia, multiple pseudopolyps on index colonoscopy, or a first-degree relative with CRC. There were no differences in colonoscopy quality measures between patients with and without IBD.

conclusionsThis study stresses the importance of strict short-interval surveillance for IBD patients with high-risk features, including active inflammation on index colonoscopy.

Indexed as

AdenocarcinomaAdenomatous PolypsAdultAgedColitis, UlcerativeColonic PolypsColonoscopyColorectal NeoplasmsCrohn DiseaseDatabases, FactualEarly Detection of CancerFemaleGuideline AdherenceHumansIncidenceMaleCrohn’s diseaseGuidelinesInterval colorectal neoplasiaSurveillanceUlcerative colitis

Identifiers

PMID31367882
PMCPMC6946853
OpenAlexW2966255013

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.