Evidence map›Paper›PMID 31367861›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Optic nerve sheath diameter: present and future perspectives for neurologists and critical care physicians.

Piergiorgio Lochner, Marek Czosnyka, Andrea Naldi, Epameinondas Lyros, Paolo Pelosi, Shrey Mathur, Klaus Fassbender, Chiara Robba

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. B-mode transorbital ultrasonography for the diagnosis of idiopathic intracranial hypertension: an updated systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Pooled it
  2. Intraindividual Optic Nerve Sheath Variation and Intracranial Pressure Changes: A Systematic Review and Meta-Analysis.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Pooled it
  3. Trial
  4. Trial
  5. Dynamic response of optic nerve sheath diameter to PaCOJournal of clinical monitoring and computing · 2026
    Article
  6. Article
  7. Article
  8. Observational
  9. Observational
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  11. Observational
  12. Article
  13. Article
  14. Review
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  17. Point of care ultrasound evaluation of cardio-cerebral coupling.World journal of critical care medicine · 2025
    Review
  18. Article
  19. Article
  20. Advancements in Non-Invasive Intracranial Pressure Monitoring via Optic Nerve Sheath Diameter Measurement.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Piergiorgio LochnerDepartment of Neurology, Saarland University Medical Center, Homburg, Germany. piergiorgio.lochner@uks.eu.ORCID http://orcid.org/0000-0002-2101-6066
Marek CzosnykaDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University, Cambridge, UK.
Andrea NaldiDepartment of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
Epameinondas LyrosDepartment of Neurology, Saarland University Medical Center, Homburg, Germany.
Paolo PelosiAnesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.
Shrey MathurDepartment of Neurology, Saarland University Medical Center, Homburg, Germany.
Klaus FassbenderDepartment of Neurology, Saarland University Medical Center, Homburg, Germany.
Chiara RobbaAnesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEstimation of intracranial pressure (ICP) may be helpful in the management of neurological critically ill patients. It has been shown that ultrasonography of the optic nerve sheath diameter (ONSD) is a reliable tool for non-invasive estimation of increased intracranial pressure (ICP) at hospital admission or in intensive care. Less is known about the estimation of increased ICP and usefulness of ONSD in the prehospital setting. The aim of this review was to elucidate both prevailing and novel applications of ONSD for neurologists and critical care physicians.

methodsIn this review, we discuss the technique and the novel approach of ONSD measurement, the clinical applications of ONSD in neurology and critical care patients.

resultsONSD measurement is simple, easy to learn, and has diverse applications. ONSD has utility for ICP measurement in intracranial hemorrhage and ischemic stroke, meningitis and encephalitis, and idiopathic intracranial hypertension (IIH). It is also valuable for lesser known syndromes, where an increase of ICP is postulated, such as acute mountain sickness and posterior reversible encephalopathy syndrome. ONSD changes develop in inflammatory or ischemic optic neuropathies. Some papers demonstrate the usefulness of ONSD studies in symptomatic intracranial hypotension.

conclusionsONSD is a safe and low-cost bedside tool with the potential of screening patients who need other neuroimaging and those who may need an invasive measurement of ICP.

Indexed as

Intracranial PressureCerebrovascular DisordersCritical CareHumansMeningesNeuroimagingNeurologyOptic NerveUltrasonographyAcute mountain sickness (AMS)Intracranial pressure (ICP)Optic nerveOptic nerve sheath diameter (ONSD)Symptomatic intracranial hypotension (SIH)Transorbital ultrasonography (TSO)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.