ArticleGigaScience2019
An integrated respiratory microbial gene catalogue to better understand the microbial aetiology of Mycoplasma pneumoniae pneumonia.
Article in GigaScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
- Microbiota diversity and differences in the respiratory tract of children with pneumonia.Pediatric investigation · 2025Article
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- Comprehensive human respiratory genome catalogue underlies the high resolution and precision of the respiratory microbiome.Briefings in bioinformatics · 2024Article
- Integrated large-scale metagenome assembly and multi-kingdom network analyses identify sex differences in the human nasal microbiome.Genome biology · 2024Article
- Next-Generation Sequencing for Characterizing Respiratory Tract Virome and Improving Detection of Viral Pathogens in Children With Pneumonia.Influenza and other respiratory viruses · 2024Article
- Database size positively correlates with the loss of species-level taxonomic resolution for the 16S rRNA and other prokaryotic marker genes.PLoS computational biology · 2024Article
- Article
- Integrative study of pulmonary microbiome, transcriptome and clinical outcomes in Mycoplasma pneumoniae pneumonia.Respiratory research · 2024Article
- Characterization of the pig lower respiratory tract antibiotic resistome.Nature communications · 2023Article
- Narrative review of application of metagenomic approaches to study the link between oropharyngeal microbiome and infectious diseases.Frontiers in microbiology · 2023Review
- The gut microbiome as a potential source of non-invasive biomarkers of chronic obstructive pulmonary disease.Frontiers in microbiology · 2023Article
- Human airway and lung microbiome at the crossroad of health and disease (Review).Experimental and therapeutic medicine · 2023Review
- Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions.Nature microbiology · 2022Article
- Clinical Analysis and Risk Factors of Bronchiolitis Obliterans After Mycoplasma Pneumoniae Pneumonia.Infection and drug resistance · 2022Article
- Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome.Journal of oral microbiology · 2022Article
- Microbiota, probiotics and respiratory infections: the three musketeers can tip off potential management of COVID-19.American journal of translational research · 2021Review
- The Role of Respiratory Flora in the Pathogenesis of Chronic Respiratory Diseases.BioMed research international · 2021Review
- An integrated respiratory microbial gene catalogue to better understand the microbial aetiology of Mycoplasma pneumoniae pneumonia.GigaScience · 2019Article
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Authors and funding
22 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe imbalanced respiratory microbiota observed in pneumonia causes high morbidity and mortality in childhood. Respiratory metagenomic analysis demands a comprehensive microbial gene catalogue, which will significantly advance our understanding of host-microorganism interactions.
resultsWe collected 334 respiratory microbial samples from 171 healthy children and 76 children with pneumonia. The respiratory microbial gene catalogue we established comprised 2.25 million non-redundant microbial genes, covering 90.52% of prevalent genes. The major oropharyngeal microbial species found in healthy children were Prevotella and Streptococcus. In children with Mycoplasma pneumoniae pneumonia (MPP), oropharyngeal microbial diversity and associated gene numbers decreased compared with those of healthy children. The concurrence network of oropharyngeal microorganisms in patients predominantly featured Staphylococcus spp. and M. pneumoniae. Functional orthologues, which are associated with the metabolism of various lipids, membrane transport, and signal transduction, accumulated in the oropharyngeal microbiome of children with pneumonia. Several antibiotic resistance genes and virulence factor genes were identified in the genomes of M. pneumoniae and 13 other microorganisms reconstructed via metagenomic data. Although the common macrolide/β-lactam resistance genes were not identified in the assembled M. pneumoniae genome, a single-nucleotide polymorphism (A2063G) related to macrolide resistance was identified in a 23S ribosomal RNA gene.
conclusionsThe results of this study will facilitate exploration of unknown microbial components and host-microorganism interactions in studies of the respiratory microbiome. They will also yield further insights into the microbial aetiology of MPP.
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