Evidence map›Paper›PMID 31367586›Full record

ArticleOcular oncology and pathology2019

Regression of Sebaceous Carcinoma of the Eyelid after a Small Incisional Biopsy: Report of Two Cases.

Seymour Brownstein, Sonul Mehta, Navdeep Nijhawan, Guy Allaire, Tuan Quynh Tram Nguyen, Tina Tang, Kailun Jiang, Solin Saleh, Evan Kalin-Hajdu, Robbin Bruen and 1 more

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Seymour BrownsteinDepartment of Ophthalmology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
Sonul MehtaDepartment of Ophthalmology, University of Toronto, Toronto, Ontario, Canada.
Navdeep NijhawanDepartment of Ophthalmology, University of Toronto, Toronto, Ontario, Canada.
Guy AllaireDepartment of Pathology, University of Montreal, Montreal, Québec, Canada.
Tuan Quynh Tram NguyenDepartment of Ophthalmology, University of Montreal, Montreal, Québec, Canada.
Tina TangDepartment of Ophthalmology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
Kailun JiangDepartment of Ophthalmology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
Solin SalehDepartment of Ophthalmology, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.
Evan Kalin-HajduDepartment of Ophthalmology, University of Montreal, Montreal, Québec, Canada.
Robbin BruenDepartment of Ophthalmology, University of Montreal, Montreal, Québec, Canada.
James OestrelcherDepartment of Ophthalmology, University of Toronto, Toronto, Ontario, Canada.
Université de Montréal · CAUniversity of Toronto · CAOttawa Hospital · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report 2 cases of regression of sebaceous carcinoma of the eyelid after a small incisional biopsy.

methodsClinical, imaging, and histopathological findings are presented, with a literature review on regressing ocular tumors.

resultsOur first patient was a 79-year-old man who presented with a 10-month history of progressive left upper eyelid ptosis caused by an eyelid tumor with orbital involvement and confirmed on magnetic resonance imaging. Our second patient was a 70-year-old woman who presented with ptosis with a left upper eyelid mass. Both patients underwent a small incisional biopsy of their lesion. The histopathological diagnoses in both cases were consistent with sebaceous carcinoma. Both patients refused exenteration. Follow-up clinical examination and imaging disclosed total regression of the ptosis and of the neoplasm with no sign of recurrence in both patients over a 4-year period for Case 1 and a 7-year period for Case 2.

conclusionRegression following incisional biopsy of basal cell, squamous cell, and Merkel cell carcinoma, including of the eyelid, is well documented. To the best of our knowledge, our 2 cases of sebaceous carcinoma are the first to be reported with total involution clinically and on imaging of the tumor following partial incisional biopsy.

Indexed as

ExenterationEyelidOrbitPtosisSebaceous carcinomaSmall incisional biopsySpontaneous regression

Identifiers

PMID31367586
PMCPMC6615332
OpenAlexW2898859752

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.