Evidence map›Paper›PMID 31367295›Full record

ArticleMolecular autism2019

Behavioral characteristics of autism spectrum disorder in very preterm birth children.

Li-Wen Chen, Shan-Tair Wang, Lan-Wan Wang, Yu-Chia Kao, Ching-Lin Chu, Chin-Chin Wu, Yi-Ting Hsieh, Chung-Hsin Chiang, Chao-Ching Huang

Abstract read
In one paragraph

Article in Molecular autism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  9. [Recent research on the long-term neurodevelopmental outcomes of very preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Review
  10. Article
  11. Article
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  13. Comparing autism phenotypes in children born extremely preterm and born at term.Autism research : official journal of the International Society for Autism Research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li-Wen Chen1Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 70403 Taiwan.ORCID 0000-0002-4013-8333
Shan-Tair Wang3Graduate Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lan-Wan Wang4Department of Pediatrics, Chi-Mei Medical Center, Tainan, Taiwan.
Yu-Chia Kao2Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ching-Lin Chu8Department of Educational Psychology and Counseling, National Pingtung University, Pingtung, Taiwan.
Chin-Chin Wu9Department of Psychology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yi-Ting Hsieh10Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chung-Hsin Chiang11Department of Psychology, National Chengchi University, Taipei, Taiwan.
Chao-Ching Huang1Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 70403 Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lower gestational age may increase autism spectrum disorder (ASD) vulnerability; however, the incidence of ASD diagnosis through a direct assessment on every very preterm birth child on the population base remains unclear. Moreover, the behavioral characteristics of preterm birth ASD are unknown. Methods: Every very preterm birth child (gestational age < 32 weeks; birth weight < 1500 g) who was discharged from neonatal intensive care units in Southern Taiwan and prospectively followed to 5 years of age was evaluated using the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R). The term birth (gestational age > 37 weeks) ASD children characterized by ADOS and ADI-R were group matched to the preterm birth ASD by age at examination for comparison. ADOS severity scores were calculated by the Mann-Whitney Results: Two hundred forty-six (87%) of the 283 very preterm survivors were followed prospectively to 5 years of age. Nineteen (7.7%) of the 246 children fulfilled the diagnostic criteria of ASD. After excluding 1 patient with cerebral palsy and profound mental disability, 18 preterm ASD children were compared with 44 term birth ASD children. The two ASD groups were comparable for age at examination, gender, and intelligence quotient. The two groups showed comparable ADOS severity scores in social affect deficits, restricted repetitive behaviors, and total score, but had differences in qualitative abnormalities in reciprocal social interaction (Wilks lambda Conclusions: The 5-year incidence rate of ASD was high in very preterm birth children. Preterm birth ASD exhibited a specific behavioral phenotype of reciprocal social interaction.

Indexed as

BehaviorAutism Spectrum DisorderChildDiscriminant AnalysisFemaleHumansInfant, Extremely PrematureInterpersonal RelationsLogistic ModelsMalePremature BirthAutism Diagnostic Interview-RevisedAutism Diagnostic Observation ScheduleAutism spectrum disorderPretermVery low birth weight

Identifiers

PMID31367295
PMCPMC6647137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.