Evidence map›Paper›PMID 31367259›Full record

ArticleTheranostics2019

Dengue and Zika Virus Domain III-Flagellin Fusion and Glycan-Masking E Antigen for Prime-Boost Immunization.

Hsiao-Han Lin, Shao-Ping Yang, Meng-Ju Tsai, Guan-Cheng Lin, Han-Chung Wu, Suh-Chin Wu

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  6. Strategies of rational and structure-driven vaccine design for Arenaviruses.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hsiao-Han LinInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Shao-Ping YangInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Meng-Ju TsaiInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Guan-Cheng LinInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
Han-Chung WuInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei 11529, Taiwan.
Suh-Chin WuInstitute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.
National Tsing Hua University · TWInstitute of Cellular and Organismic Biology, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The viral E proteins of dengue virus (DENV) and Zika virus (ZIKV) are the major viral proteins involved in receptor binding and fusion, and for the induction of protective antibodies against viral infections. DIII of the E proteins is an independent domain and stretches out on the virion surface that can elicit type-specific neutralizing antibodies. For recombinant DIII vaccine development, prime-boost immunizations can provide an advantage of eliciting more type-specific neutralizing antibodies by recalling DIII antigens after DIII booster to improve protection.

Indexed as

AnimalsAntibodies, ViralCross ReactionsDengueDengue VirusFlagellinHumansImmunizationImmunization, SecondaryMiceMice, Inbred BALB CPolysaccharidesProtein DomainsSalmonella typhimuriumViral Envelope ProteinsViral VaccinesAntibodies, ViralFlagellinPolysaccharidesViral Envelope ProteinsViral Vaccinescross-reactive antibodiesdengue and Zika virusesflagellin-domain III fusionneutralizing antibodiesprime-boost vaccines

Identifiers

PMID31367259
PMCPMC6643441
OpenAlexW2963222082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.