Evidence map›Paper›PMID 31367255›Full record

ArticleTheranostics2019

Lack of Spleen Signal on Diffusion Weighted MRI is associated with High Tumor Burden and Poor Prognosis in Multiple Myeloma: A Link to Extramedullary Hematopoiesis?

Leo Rasche, Manoj Kumar, Grant Gershner, Rohan Samant, Rudy Van Hemert, Anke Heidemeier, Constantin Lapa, Thorsten Bley, Andreas Buck, James McDonald and 10 more

Abstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Reduced splenic uptake of [EJNMMI research · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Progress of modern imaging modalities in multiple myeloma.International journal of hematology · 2022
    Review
  8. Reduced splenic uptake onTheranostics · 2022
    Article
  9. Frontiers in nuclear medicine · 2021
    Review
  10. Article
  11. The mechanisms of pathological extramedullary hematopoiesis in diseases.Cellular and molecular life sciences : CMLS · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Leo RascheMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Manoj KumarRadiology Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Grant GershnerMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rohan SamantRadiology Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rudy Van HemertRadiology Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Anke HeidemeierRadiology Department, University Hospital of Würzburg, Würzburg, Germany.
Constantin LapaDepartment of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
Thorsten BleyRadiology Department, University Hospital of Würzburg, Würzburg, Germany.
Andreas BuckDepartment of Nuclear Medicine, University Hospital of Würzburg, Würzburg, Germany.
James McDonaldRadiology Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jens HillengassRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Joshua EpsteinMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sharmilan ThanendrarajanMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Carolina SchinkeMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Frits van RheeMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Maurizio ZangariMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Bart BarlogieMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Faith E DaviesMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Gareth J MorganMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Niels WeinholdMyeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Funding

Tumor Cell-Microenvironment Interactions in the Molecular Pathogenesis of MultiplP01CA055819 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI BELLAMY, WILLIAM T · 1993 to 2013
$49.7M
Understanding the Negative Prognostic Impact of Intraosseous Focal Lesions in Multiple MyelomaP20GM125503 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Sanja Novak · 2018 to 2026
$23.0M
NCI NIH HHS P01 CA055819NIGMS NIH HHS P20 GM125503
6 · The paper itself

Abstract

Due to the low frequency of abnormalities affecting the spleen, this organ is often overlooked during radiological examinations. Here, we report on the unexpected finding, that the spleen signal on diffusion-weighted MRI (DW-MRI) is associated with clinical parameters in patients with plasma cell dyscrasias.

Indexed as

Hematopoiesis, ExtramedullaryAgedAntineoplastic AgentsDiffusion Magnetic Resonance ImagingFemaleHumansMaleMultiple MyelomaPrognosisSpleenTumor BurdenAntineoplastic Agentsdiffusion weighted mriextramedullary hematopoiesishigh riskmultiple myelomaspleentumor burden

Identifiers

PMID31367255
PMCPMC6643447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.