ArticleNature2019
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.
3 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 372 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
372citing papers in PubMed, 1 pooled it
25.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07488312 phase1enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
A Study on the Safety of Leucine-Restricted Diet in Patients With Gastric Cancer
A Study on the Safety and Efficacy of Leucine-Restricted Diet in Gastric Cancer Patients Treated With Chemotherapy and Immunotherapy
A Study on the Safety and Efficacy of Leucine-Restricted Diet in Gastric Cancer Patients Treated With Neoadjuvant Chemotherapy and Immunotherapy
Who cites it
372 citing papers in PubMed, 1 synthesis or guideline pooled it, 623 citations in OpenAlex.
- Global research trends and emerging themes in amino acid deprivation based cancer therapy: a bibliometric and visualization study.Frontiers in immunology · 2026Pooled it
- Acute effects of oral mesna administration on the full amino acid profile and 3-methylhistidine: secondary results from the CYLOB dose-finding study.Amino acids · 2024Trial
- Fine-tuning the lysine-arginine duet: a dietary approach to suppress tumor growth.Molecular biomedicine · 2026Article
- Live-cell DNMT3A "catalysome" mapping using engineered methyl-transfer pathways.Nucleic acids research · 2026Article
- Review
- MMSDH facilitates ACSL4 propionylation to counteract ferroptosis upon hypoxia and impairs PDAC chemotherapy efficacy.Nature cancer · 2026Article
- Assessment of 2-aminothiazoline-4-carboxylic acid (ATCA) formation and identification of robust serum metabolic biomarkers for acute cyanide exposure in mice fed diets with varying methionine and cystine content.Archives of toxicology · 2026Article
- Carrier-Free Nanoparticles Enhance Photothermal-Immune Therapy via Metabolic Reprogramming in Triple-Negative Breast Cancer.Advanced healthcare materials · 2026Article
- Bioinspired Artificial Bioenergetic Organelles: Design Principles, Nanofabrication and Therapeutic Translation.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Tumoral Metabolism at the Intersection of Oncogene Signaling, Epigenetics and Immunology: Emerging Therapeutic Strategies in Cancer.Current issues in molecular biology · 2026Review
- Short-term methionine starvation induces de novo diurnal oscillations of hepatic m6A RNA methylation.bioRxiv : the preprint server for biology · 2026Article
- Role of methionine metabolism in cancer: recent advances in molecular mechanisms and therapeutic implications.Experimental hematology & oncology · 2026Review
- Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster.Aging cell · 2026Article
- NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation.bioRxiv : the preprint server for biology · 2026Article
- The lethal symbiont: exploring the pathophysiology of cancer.Physiological reviews · 2026Review
- Effects of Low Methionine Intake on Gastric Ulcer in Patients and Mice: Role of the NNMT Pathway.Molecular nutrition & food research · 2026Article
- Dietary sulfur amino acids enhance anti-tumor immunity in colon cancer via an NKT cell-XCL1-cDC1 circuit.Immunity · 2026Article
- Structures of the neutral amino acid transporter LAT4 provide insights into antitumor effects of its inhibitor tubeimoside-1.The EMBO journal · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
312 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
17 authors at 4 institutions in 1 country.
Xia GaoDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Sydney M Sanderson *Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Ziwei Dai *Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Michael A ReidDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Daniel E CooperDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Min LuCenter for Genomics and Computational Biology, Duke University, Durham, NC, USA.
John P RichieDepartment of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Amy CiccarellaPenn State University Clinical Research Center, State College, PA, USA.
Ana CalcagnottoDepartment of Public Health Sciences, Penn State University College of Medicine, Hershey, PA, USA.
Peter G MikhaelDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Samantha J MentchDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Juan LiuDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Gene AblesOrentreich Foundation for the Advancement of Science, Cold Spring, NY, USA.
David G KirschDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
David S HsuCenter for Genomics and Computational Biology, Duke University, Durham, NC, USA.
Sailendra N NichenametlaOrentreich Foundation for the Advancement of Science, Cold Spring, NY, USA.
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Jason.Locasale@duke.edu.
Duke University · USDuke Medical Center · USPennsylvania State University · USOrentreich Foundation for the Advancement of Science · US
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8MWRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LOHSE, BARBARA · 1995 to 2009
$29.8MAdvancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7MDietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1MTraining Grant In Radiation BiologyT32CA093240 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREEMAN, MICHAEL L. · 2002 to 2016
$2.3MMetabolic Reprogramming of Colon Cancer Liver MetastasisR21CA201963 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W., SHEN, XILING · 2016 to 2017
$380kNCI NIH HHS P30 CA014236NCI NIH HHS R01 CA193256NCI NIH HHS R21 CA201963NCI NIH HHS R35 CA197616NCI NIH HHS T32 CA093240NCRR NIH HHS M01 RR010732
Abstract
Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component
Indexed as
Disease Models, AnimalMetabolomicsAnimalsCell Line, TumorColorectal NeoplasmsDietFemaleFluorouracilGenes, p53Genes, rasHealthy VolunteersHumansMaleMethionineMiceMiddle AgedFluorouracilMethionineSulfur
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.