Evidence map›Paper›PMID 31367038›Full record

ArticleNature2019

Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism.

Viridiana Olin-Sandoval, Jason Shu Lim Yu, Leonor Miller-Fleming, Mohammad Tauqeer Alam, Stephan Kamrad, Clara Correia-Melo, Robert Haas, Joanna Segal, David Alejandro Peña Navarro, Lucia Herrera-Dominguez and 4 more

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 163 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Age-based approach to characterize the dynamics of cellular processes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Effects ofBiology · 2025
    Article
  15. Article
  16. Article
  17. Advances in Fecal Microbiota Transplantation for Gut Dysbiosis-Related Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Viridiana Olin-SandovalDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Jason Shu Lim YuThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Leonor Miller-FlemingDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Mohammad Tauqeer AlamWarwick Medical School, University of Warwick, Coventry, UK.
Stephan KamradThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Clara Correia-MeloThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Robert HaasDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Joanna SegalThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
David Alejandro Peña NavarroDepartment of Biotechnology, BOKU - University of Natural Resources and Life Sciences, Vienna, Austria.
Lucia Herrera-DominguezThe Molecular Biology of Metabolism Laboratory, The Francis Crick Institute, London, UK.
Oscar Méndez-LucioFacultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Jakob VowinckelDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Michael MüllederDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Markus RalserDepartment of Biochemistry, University of Cambridge, Cambridge, UK. markus.ralser@crick.ac.uk.
The Francis Crick Institute · GBBiognosys (Switzerland) · CHBOKU University · ATInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXMRC Mitochondrial Biology Unit · GBUniversidad Nacional Autónoma de México · MXUniversity of Cambridge · GBUniversity of Warwick · GB

Funding

Austrian Science Fund FWF W 1224European Research Council 260809Medical Research Council FC001134Wellcome Trust 200829Wellcome Trust FC001134
6 · The paper itself

Abstract

Both single and multicellular organisms depend on anti-stress mechanisms that enable them to deal with sudden changes in the environment, including exposure to heat and oxidants. Central to the stress response are dynamic changes in metabolism, such as the transition from the glycolysis to the pentose phosphate pathway-a conserved first-line response to oxidative insults

Indexed as

AntioxidantsAntiportersCadaverineGlutamineGlutathioneLysineNADPOrganic Cation Transport ProteinsOrnithine DecarboxylaseOxidantsPolyaminesReactive Oxygen SpeciesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntioxidantsAntiportersCadaverineGlutamineGlutathioneLysineNADPOrganic Cation Transport ProteinsOrnithine DecarboxylaseOxidantsPolyaminesReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsSPE1 protein, S cerevisiaeTPO1 protein, S cerevisiae

Identifiers

PMID31367038
PMCPMC6774798
OpenAlexW2964703879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.