Evidence map›Paper›PMID 31366733›Full record

ArticleThe Journal of biological chemistry2019

Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket.

Jennifer K Chik, Vera Moiseeva, Pavitra K Goel, Ben A Meinen, Philipp Koldewey, Sojin An, Barbara G Mellone, Lakxmi Subramanian, Uhn-Soo Cho

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Structure and function of the centromere and inner kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. Centromeres drive and take a break.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Cell cycle control of kinetochore assembly.Nucleus (Austin, Tex.) · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jennifer K ChikDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109.ORCID 0000-0003-4968-5082
Vera MoiseevaSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Pavitra K GoelSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom.
Ben A MeinenDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109.
Philipp KoldeweyDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109.
Sojin AnDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109.
Barbara G MelloneInstitute for Systems Genomics, University of Connecticut, Storrs, Connecticut 06269.
Lakxmi SubramanianSchool of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom l.subramanian@qmul.ac.uk.ORCID 0000-0001-8726-2422
Uhn-Soo ChoDepartment of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109 uhnsoo@med.umich.edu.ORCID 0000-0002-6992-2455
University of Michigan · USQueen Mary University of London · GBUniversity of Connecticut · US

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
The molecular mechanisms of nutrient- and stress-dependent mTORC1 regulation mediated by human Sestrin2.R01DK111465 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHO, UHN-SOO · 2016 to 2020
$2.4M
A novel animal model approach to investigate neocentromere formation and inactivaR01GM108829 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI MELLONE, BARBARA · 2014 to 2018
$1.5M
Biotechnology and Biological Sciences Research Council BB/R00868X/1NIDDK NIH HHS R01 DK111465NIGMS NIH HHS R01 GM108829NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

The successful assembly and regulation of the kinetochore are critical for the equal and accurate segregation of genetic material during the cell cycle. CENP-C (centromere protein C), a conserved inner kinetochore component, has been broadly characterized as a scaffolding protein and is required for the recruitment of multiple kinetochore proteins to the centromere. At its C terminus, CENP-C harbors a conserved cupin domain that has an established role in protein dimerization. Although the crystal structure of the

Indexed as

AnimalsCell Cycle ProteinsCentromereCentromere Protein AChromosomal Proteins, Non-HistoneCrystallography, X-RayDimerizationDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsHistonesKinetochoresSchizosaccharomycesSchizosaccharomyces pombe ProteinsCell Cycle ProteinsCENP-C protein, DrosophilaCentromere Protein Acentromere protein CChromosomal Proteins, Non-HistoneDNA-Binding ProteinsDrosophila ProteinsHistonesMoa1 protein, S pombeSchizosaccharomyces pombe Proteinsanalytical ultracentrifugationCENP-Ccentromerecupin domainfission yeastkinetochoremeiosisMoa1X-ray crystallography

Identifiers

PMID31366733
PMCPMC6755791
OpenAlexW2964879814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.