Evidence map›Paper›PMID 31366728›Full record

ArticleThe Journal of biological chemistry2019

CNS cell type-specific gene profiling of P301S tau transgenic mice identifies genes dysregulated by progressive tau accumulation.

Yazi D Ke, Gabriella Chan, Kristie Stefanoska, Carol Au, Mian Bi, Julius Müller, Magdalena Przybyla, Astrid Feiten, Emmanuel Prikas, Glenda M Halliday and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Yazi D KeDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Gabriella ChanDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Kristie StefanoskaDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Carol AuDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Mian BiDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.ORCID 0000-0002-4383-3606
Julius MüllerThe Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, United Kingdom.ORCID 0000-0002-1046-2968
Magdalena PrzybylaDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Astrid FeitenDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.ORCID 0000-0002-9134-2852
Emmanuel PrikasDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.ORCID 0000-0001-8833-2728
Glenda M HallidayBrain and Mind Centre, University of Sydney, Sydney, New South Wales 2005, Australia.ORCID 0000-0003-0422-8398
Olivier PiguetBrain and Mind Centre, University of Sydney, Sydney, New South Wales 2005, Australia.
Matthew C KiernanBrain and Mind Centre, University of Sydney, Sydney, New South Wales 2005, Australia.
Michael KassiouSchool of Chemistry, University of Sydney, Sydney, New South Wales 2005, Australia.
John R HodgesBrain and Mind Centre, University of Sydney, Sydney, New South Wales 2005, Australia.
Clement T LoyGarvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
John S MattickGarvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia.
Arne IttnerDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Jillian J KrilCharles Perkins Centre and Discipline of Pathology, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales 2005, Australia.
Greg T SutherlandCharles Perkins Centre and Discipline of Pathology, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales 2005, Australia.
Lars M IttnerDementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia lars.ittner@mq.edu.au.
Macquarie University · AUThe University of Sydney · AUGarvan Institute of Medical Research · AUUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microtubule-associated protein tau undergoes aberrant modification resulting in insoluble brain deposits in various neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy, and corticobasal degeneration. Tau aggregates can form in different cell types of the central nervous system (CNS) but are most prevalent in neurons. We have previously recapitulated aspects of human FTD in mouse models by overexpressing mutant human tau in CNS neurons, including a P301S tau variant in TAU58/2 mice, characterized by early-onset and progressive behavioral deficits and FTD-like neuropathology. The molecular mechanisms underlying the functional deficits of TAU58/2 mice remain mostly elusive. Here, we employed functional genomics (

Indexed as

Alzheimer DiseaseAnimalsBrainCentral Nervous SystemDisease Models, AnimalFrontotemporal DementiaGene Expression RegulationHumansMiceMice, TransgenicNeuronsSequence Analysis, RNATauopathiestau Proteinstau Proteinsgene expressionmouseneurobiologyneurodegenerative diseaseTau protein (Tau)transgenic mice

Identifiers

PMID31366728
PMCPMC6755788
OpenAlexW2966537749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.