Evidence map›Paper›PMID 31366629›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Phase separation and clustering of an ABC transporter in

Florian Heinkel, Libin Abraham, Mary Ko, Joseph Chao, Horacio Bach, Lok Tin Hui, Haoran Li, Mang Zhu, Yeou Mei Ling, Jason C Rogalski and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 87 citations in OpenAlex.

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  11. Mechanisms and Pathological Significance of Liquid-Liquid Phase Separation in Bacteria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
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  15. Molecular biology of the cell · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Florian HeinkelMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Libin AbrahamDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.ORCID 0000-0002-4725-3502
Mary KoDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
Joseph ChaoDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Horacio BachDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada V6H 3Z6.
Lok Tin HuiDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Haoran LiMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Mang ZhuMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Yeou Mei LingDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Jason C RogalskiMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Joshua ScurllDepartment of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, BC, Canada V6T 1Z2.
Jennifer M BuiMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Thibault MayorMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.
Michael R GoldDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Keng C ChouDepartment of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1.
Yossef Av-GayDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.
Lawrence P McIntoshMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; mcintosh@chem.ubc.ca gsponer@msl.ubc.ca.
Jörg GsponerMichael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4; mcintosh@chem.ubc.ca gsponer@msl.ubc.ca.
University of British Columbia · CA

Funding

CIHR MOP-106622CIHR MOP-136834
6 · The paper itself

Abstract

Phase separation drives numerous cellular processes, ranging from the formation of membrane-less organelles to the cooperative assembly of signaling proteins. Features such as multivalency and intrinsic disorder that enable condensate formation are found not only in cytosolic and nuclear proteins, but also in membrane-associated proteins. The ABC transporter Rv1747, which is important for

Indexed as

ATP-Binding Cassette TransportersCytosolGene Expression Regulation, BacterialHumansLipid BilayersMembrane ProteinsMycobacterium smegmatisMycobacterium tuberculosisNuclear ProteinsPhosphorylationSignal TransductionSingle Molecule ImagingTuberculosisATP-Binding Cassette TransportersLipid BilayersMembrane ProteinsNuclear ProteinsRv1747 protein, Mycobacterium tuberculosisABC transporterFHA domainnanoclusteringphase separation

Identifiers

PMID31366629
PMCPMC6697873
OpenAlexW2966690555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.