Evidence map›Paper›PMID 31366612›Full record

ReviewClinical microbiology reviews2019

Consumer Safety Considerations of Skin and Oral Microbiome Perturbation.

Andrew J McBain, Catherine A O'Neill, Alejandro Amezquita, Laura J Price, Karoline Faust, Adrian Tett, Nicola Segata, Jonathan R Swann, Adrian M Smith, Barry Murphy and 8 more

Abstract readReview
In one paragraph

Review in Clinical microbiology reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
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  4. Effects of glucose and lactate onMicrobiology spectrum · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrew J McBainDivision of Pharmacy & Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom andrew.mcbain@manchester.ac.uk.ORCID 0000-0002-5255-5425
Catherine A O'NeillDivision of Musculoskeletal & Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, United Kingdom.
Alejandro AmezquitaUnilever, Safety & Environmental Assurance Centre (SEAC), Sharnbrook, United Kingdom.
Laura J PriceUnilever, Safety & Environmental Assurance Centre (SEAC), Sharnbrook, United Kingdom.
Karoline FaustDepartment of Microbiology, Immunology and Transplantation, Laboratory of Molecular Bacteriology, Rega Institute, Leuven, Belgium.ORCID 0000-0001-7129-2803
Adrian TettDepartment CIBIO, University of Trento, Trento, Italy.
Nicola SegataDepartment CIBIO, University of Trento, Trento, Italy.ORCID 0000-0002-1583-5794
Jonathan R SwannDivision of Integrative Systems Medicine and Digestive Diseases, Imperial College London, London, United Kingdom.ORCID 0000-0002-6485-4529
Adrian M SmithUnilever, Sharnbrook, United Kingdom.
Barry MurphyUnilever, Port Sunlight, United Kingdom.
Michael HoptroffUnilever, Port Sunlight, United Kingdom.
Gordon JamesUnilever, Sharnbrook, United Kingdom.
Yugandhar ReddyUnilever, Bangalore, India.
Anindya DasguptaUnilever, Bangalore, India.
Tom RossUniversity of Tasmania, Hobart, Tasmania, Australia.
Iain L ChapplePeriodontal Research Group, The University of Birmingham, Birmingham, United Kingdom.
William G WadeCentre for Host-Microbiome Interactions, King's College London, London, United Kingdom.ORCID 0000-0003-2685-826X
Judith Fernandez-PiquerUnilever, Safety & Environmental Assurance Centre (SEAC), Sharnbrook, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbiomes associated with human skin and the oral cavity are uniquely exposed to personal care regimes. Changes in the composition and activities of the microbial communities in these environments can be utilized to promote consumer health benefits, for example, by reducing the numbers, composition, or activities of microbes implicated in conditions such as acne, axillary odor, dandruff, and oral diseases. It is, however, important to ensure that innovative approaches for microbiome manipulation do not unsafely disrupt the microbiome or compromise health, and where major changes in the composition or activities of the microbiome may occur, these require evaluation to ensure that critical biological functions are unaffected. This article is based on a 2-day workshop held at SEAC Unilever, Sharnbrook, United Kingdom, involving 31 specialists in microbial risk assessment, skin and oral microbiome research, microbial ecology, bioinformatics, mathematical modeling, and immunology. The first day focused on understanding the potential implications of skin and oral microbiome perturbation, while approaches to characterize those perturbations were discussed during the second day. This article discusses the factors that the panel recommends be considered for personal care products that target the microbiomes of the skin and the oral cavity.

Indexed as

Consumer Product SafetyCosmeticsEducationHumansMicrobiotaMouthSkinCosmeticsconsumer safetyhygieneoral microbiomepersonal carerisk assessmentskin microbiome

Identifiers

PMID31366612
PMCPMC6750131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.