Evidence map›Paper›PMID 31366396›Full record

ArticleTrials2019

The redox-dependent regulation of satellite cells following aseptic muscle trauma (SpEED): study protocol for a randomized controlled trial.

Konstantinos Papanikolaou, Dimitrios Draganidis, Athanasios Chatzinikolaou, Vassiliki C Laschou, Kalliopi Georgakouli, Panagiotis Tsimeas, Alexios Batrakoulis, Chariklia K Deli, Athanasios Z Jamurtas, Ioannis G Fatouros

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03711838 (The Effect of Redox Potential on the Regulation of Satellite Cells and Skeletal Muscle Healing Following Exercise-Induced Muscle Damage), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03711838 nacompletednot on this map

The Effect of Redox Potential on the Regulation of Satellite Cells and Skeletal Muscle Healing Following Exercise-Induced Muscle Damage

TypeinterventionalSponsorUniversity of ThessalyRan2019 to 2022Enrolled45ConditionsSatellite Cells, Redox Status, Exercise-induced Muscle Trauma, Aseptic InflammationArmsN-Acetylcysteine, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Konstantinos PapanikolaouSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Dimitrios DraganidisSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Athanasios ChatzinikolaouSchool of Physical Education and Sport Sciences, Democritus University of Thrace, 69100, Komotini, Greece.
Vassiliki C LaschouSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Kalliopi GeorgakouliSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Panagiotis TsimeasSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Alexios BatrakoulisSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Chariklia K DeliSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Athanasios Z JamurtasSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece.
Ioannis G FatourosSchool of Physical Education, Sport Sciences and Dietetics, University of Thessaly, Karies, 42100, Trikala, Greece. ifatouros@pe.uth.gr.ORCID http://orcid.org/0000-0002-8475-8411
University of Thessaly · GRDemocritus University of Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMuscle satellite cells (SCs) are crucial for muscle regeneration following muscle trauma. Acute skeletal muscle damage results in inflammation and the production of reactive oxygen species (ROS) which may be implicated in SCs activation. Protection of these cells from oxidative damage is essential to ensure sufficient muscle regeneration. The aim of this study is to determine whether SCs activity under conditions of aseptic skeletal muscle trauma induced by exercise is redox-dependent. METHODS/

designBased on the SCs content in their vastus lateralis skeletal muscle, participants will be classified as either high or low respondents. In a randomized, double-blind, crossover, repeated-measures design, participants will then receive either placebo or N-acetylcysteine (alters redox potential in muscle) during a preliminary 7-day loading phase, and for eight consecutive days following a single bout of intense muscle-damaging exercise. In both trials, blood samples and muscle biopsies will be collected, and muscle performance and soreness will be measured at baseline, pre-exercise, 2 and 8 days post exercise. Biological samples will be analyzed for redox status and SCs activity. Between trials, a 4-week washout period will be implemented. DISCUSSION: This study is designed to investigate the impact of redox status on SCs mobilization and thus skeletal muscle potential for regeneration under conditions of aseptic inflammation induced by exercise. Findings of this trial should provide insight into (1) molecular pathways involved in SCs recruitment and muscle healing under conditions of aseptic skeletal muscle trauma present in numerous catabolic conditions and (2) whether skeletal muscle's potential for regeneration depends on its basal SCs content.

trial registrationClinicalTrials.gov, ID: NCT03711838 . Registered on 19 Oct 2018.

Indexed as

ExerciseAcetylcysteineAdolescentAdultAntioxidantsCross-Over StudiesDouble-Blind MethodGreeceHumansMaleMyalgiaOxidation-ReductionOxidative StressQuadriceps MuscleRandomized Controlled Trials as TopicRegenerationAcetylcysteineAntioxidantsAntioxidantsCell signalingMuscle stem cellsRedox potentialTissue regeneration

Identifiers

PMID31366396
PMCPMC6668149
OpenAlexW2965351787

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.