Evidence map›Paper›PMID 31366377›Full record

ArticleActa neuropathologica communications2019

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis.

Jing Jin, Matthew D Smith, Calvin J Kersbergen, Tae-In Kam, Mayuri Viswanathan, Kyle Martin, Ted M Dawson, Valina L Dawson, Donald J Zack, Katharine Whartenby and 1 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 70 citations in OpenAlex.

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  14. Non-invasiveFrontiers in cellular neuroscience · 2024
    Review
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  17. Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis.Annals of clinical and translational neurology · 2023
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jing JinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Matthew D SmithDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Calvin J KersbergenDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Tae-In KamNeuroregeneration and Stem Cell Programs Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Mayuri ViswanathanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Kyle MartinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Ted M DawsonDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Valina L DawsonDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Donald J ZackDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Katharine WhartenbyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. Calabresi@jhmi.edu.ORCID 0000-0002-7776-6472
Johns Hopkins University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
Mechanisms by which effector T cells modulate endogenous remyelinationR37NS041435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CALABRESI, PETER A · 2013 to 2019
$3.0M
NIGMS NIH HHS T32 GM007309NIH HHS NS-R37041435NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS041435NINDS NIH HHS R37 NS041435
6 · The paper itself

Abstract

The animal model experimental autoimmune encephalomyelitis (EAE) has been used extensively in the past to test mechanisms that target peripheral immune cells for treatment of multiple sclerosis (MS). While there have been some notable successes in relapsing MS, the development of therapies for progressive multiple sclerosis (MS) has been hampered by lack of an appropriate animal model. Further, the mechanisms underlying CNS inflammation and neuronal injury remain incompletely elucidated. It is known that the MOG

Indexed as

AnimalsEncephalomyelitis, Autoimmune, ExperimentalFemaleMaleMice, Inbred C57BLMultiple SclerosisNeurogliaOptic NerveRetinaRetinal Ganglion CellsVisual PathwaysAstrocytesEAEOptic neuritisRetinal ganglion cells

Identifiers

PMID31366377
PMCPMC6670238
OpenAlexW2964369280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.