ArticleVeterinary research2019
Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe.
Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Novel Prion Protein Gene (bioRxiv : the preprint server for biology · 2026Article
- Identification and initial characterization of novel prion protein gene (Frontiers in veterinary science · 2026Article
- The Strain Properties of Korean and North American Chronic Wasting Disease Prions Are Indistinguishable.The Journal of infectious diseases · 2025Article
- Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity.Neurobiology of disease · 2025Article
- Variation in the prion protein gene (PRNP) open reading frame sequence in French cervids.Veterinary research · 2024Article
- Prion protein gene (PRNP) variation in German and Danish cervids.Veterinary research · 2024Article
- Article
- Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification.Veterinary research · 2023Article
- Heterogeneity of pathological prion protein accumulation in the brain of moose (Alces alces) from Norway, Sweden and Finland with chronic wasting disease.Veterinary research · 2023Article
- Monitoring of chronic wasting disease (CWD) (IV).EFSA journal. European Food Safety Authority · 2023Article
- New developments in prion disease research using genetically modified mouse models.Cell and tissue research · 2023Review
- Article
- Chronic wasting disease in Europe: new strains on the horizon.Acta veterinaria Scandinavica · 2021Review
- Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae.Veterinary research · 2021Review
- Article
- Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis.International journal of molecular sciences · 2021Review
- Article
- Article
- Large-scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility.Molecular ecology · 2020Article
- Update on chronic wasting disease (CWD) III.EFSA journal. European Food Safety Authority · 2019Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Susceptibility to prion diseases is largely determined by the sequence of the prion protein gene (PRNP), which encodes the prion protein (PrP). The recent emergence of chronic wasting disease (CWD) in Europe has highlighted the need to investigate PRNP gene diversity in European deer species, to better predict their susceptibility to CWD. Here we report a large genetic survey of six British deer species, including red (Cervus elaphus), sika (Cervus nippon), roe (Capreolus capreolus), fallow (Dama dama), muntjac (Muntiacus reevesii), and Chinese water deer (Hydropotes inermis), which establishes PRNP haplotype and genotype frequencies. Two smaller data sets from red deer in Norway and the Czech Republic are also included for comparison. Overall red deer show the most PRNP variation, with non-synonymous/coding polymorphisms at codons 98, 168, 226 and 247, which vary markedly in frequency between different regions. Polymorphisms P168S and I247L were only found in Scottish and Czech populations, respectively. T98A was found in all populations except Norway and the south of England. Significant regional differences in genotype frequencies were observed within both British and European red deer populations. Other deer species showed less variation, particularly roe and fallow deer, in which identical PRNP gene sequences were found in all individuals analysed. Based on comparison with PRNP sequences of North American cervids affected by CWD and limited experimental challenge data, these results suggest that a high proportion of wild deer in Great Britain may be susceptible to CWD.
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