ArticleGenome biology2019
HUPAN: a pan-genome analysis pipeline for human genomes.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Current State of Fish Reference Genome and Pangenome: Methodologies, Sampling Strategies, Quality Assessment and Future Perspectives to Aquaculture Breeding.Marine biotechnology (New York, N.Y.) · 2025Review
- Pan-Genome Analysis ofInternational journal of molecular sciences · 2025Article
- APAV: An advanced pangenome analysis and visualization toolkit.PLoS computational biology · 2025Article
- Common bean pan-genome reveals abundant variation patterns and relationships of stress response genes and pathways.BMC genomics · 2025Article
- Constructing a draft Indian cattle pangenome using short-read sequencing.Communications biology · 2025Article
- Population genomics advances in frontier ethnic minorities in China.Science China. Life sciences · 2025Review
- The pan-genome of Spodoptera frugiperda provides new insights into genome evolution and horizontal gene transfer.Communications biology · 2025Article
- Current and future pangenomic research in cucurbit crops.Breeding science · 2025Article
- Advancing the Indian cattle pangenome: characterizing non-reference sequences in Bos indicus.Journal of animal science and biotechnology · 2025Article
- Pangenome Reveals Gene Content Variations and Structural Variants Contributing to Pig Characteristics.Genomics, proteomics & bioinformatics · 2025Article
- Beyond single references: pangenome graphs and the future of genomic medicine.Frontiers in genetics · 2025Review
- Pangenome graphs and their applications in biodiversity genomics.Nature genetics · 2025Review
- A gentle introduction to pangenomics.Briefings in bioinformatics · 2024Review
- PPanG: a precision pangenome browser enabling nucleotide-level analysis of genomic variations in individual genomes and their graph-based pangenome.BMC genomics · 2024Article
- Human pangenome: far-reaching implications in precision medicine.Frontiers of medicine · 2024Article
- Human pangenome analysis of sequences missing from the reference genome reveals their widespread evolutionary, phenotypic, and functional roles.Nucleic acids research · 2024Article
- Article
- Emerging trends in clinical cancer genomic research.Cancer biology & medicine · 2023Article
- The pig pangenome provides insights into the roles of coding structural variations in genetic diversity and adaptation.Genome research · 2023Article
- A pangenome reference of 36 Chinese populations.Nature · 2023Article
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Authors and funding
16 authors.
Funding
Abstract
The human reference genome is still incomplete, especially for those population-specific or individual-specific regions, which may have important functions. Here, we developed a HUman Pan-genome ANalysis (HUPAN) system to build the human pan-genome. We applied it to 185 deep sequencing and 90 assembled Han Chinese genomes and detected 29.5 Mb novel genomic sequences and at least 188 novel protein-coding genes missing in the human reference genome (GRCh38). It can be an important resource for the human genome-related biomedical studies, such as cancer genome analysis. HUPAN is freely available at http://cgm.sjtu.edu.cn/hupan/ and https://github.com/SJTU-CGM/HUPAN .
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