ArticleBMC anesthesiology2019
Effect of opioid-free anaesthesia on post-operative period in cardiac surgery: a retrospective matched case-control study.
Article in BMC anesthesiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypas
General Anesthesia Usiing Fentanyl Plus Propofol Plus Rococuronium Plus Isoflurane Versus Ketamime Plus Magnesium Sulphate Plus Lidocaine Plus Clonidine Plus Propofol Plus Rococuronium Plus Isoflurane in Gynaecology Surgery
The Postoperative Opioid-Sparing Effect of an Intraoperative Pecto-Intercostal Fascial Block and Opioid-Free Anesthesia in Cardiac Surgery Patients: a Prospective Randomized Controlled Trial
Who cites it
34 citing papers in PubMed.
- Trial
- Evaluation of the Effect of New Multimodal Analgesia Regimen for Cardiac Surgery: A Prospective, Randomized Controlled, Single-Center Clinical Study.Drug design, development and therapy · 2023Trial
- Nociception Level Index-Directed Erector Spinae Plane Block in Open Heart Surgery: A Randomized Controlled Clinical Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Trial
- Trial
- Pupillometric Monitoring of Nociception in Cardiac Anesthesia.Deutsches Arzteblatt international · 2020Trial
- Pupillometry pain index decreases intraoperative sufentanyl administration in cardiac surgery: a prospective randomized study.Scientific reports · 2020Trial
- The effect of scheduled metamizole on opioid consumption after cardiac surgery.Frontiers in pharmacology · 2026Article
- An Emerging Paradigm for Safer and Faster Recovery: A Narrative Review on Opioid Sparing Anesthesia in Surgery.Cureus · 2025Review
- Trajectories of Pain in Low-Opioid and Opioid-Based Postoperative Analgesia in Older Patients-Perioperative Clinical Study.Journal of clinical medicine · 2025Article
- Quality of recovery (QoR-15) following opioid-free versus opioid anaesthesia for elective endoscopic nasal surgeries: A randomised, open-label comparative trial.Indian journal of anaesthesia · 2025Article
- Enhanced Recovery After Surgery (ERAS) Protocols in Cardiac Surgery: Impact on Opioid Consumption.Journal of clinical medicine · 2025Article
- A review of recent advances in anesthetic drugs for patients undergoing cardiac surgery.Frontiers in pharmacology · 2025Review
- Research Trends and Knowledge Mapping of Opioid-Free Anesthesia: A Global Bibliometric Analysis.Journal of multidisciplinary healthcare · 2025Article
- Opioid-Free Anesthesia for Upper Limb Surgery in Obese Patients as a Day Case Surgery: A Prospective Observational Study.Anesthesiology and pain medicine · 2024Article
- Article
- Optimizing Postoperative Pain Management After Cytoreductive Surgery: Time to Break Old Habits and Usher in More Interdisciplinary Collaboration.Annals of surgical oncology · 2024Article
- Pre-operative maintenance of angiotensin-converting enzyme inhibitors is not associated with acute kidney injury in cardiac surgery patients with cardio-pulmonary bypass: a propensity-matched multicentric analysis.Frontiers in pharmacology · 2024Article
- Opioid Free Total Intravenous Anesthesia With Dexmedetomidine-Esketamine-Lidocaine for Patients Undergoing Lumpectomy.Journal of clinical medicine research · 2023Article
- Protocol Study for the Evaluation of Non-Opioid Balanced General Anaesthesia in Cardiac Surgery with Cardiopulmonary Bypass: A Randomised, Controlled, Multicentric Superiority Trial (OFACAR Study).Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNo study has been conducted to demonstrate the feasibility of an opioid-free anesthesia (OFA) protocol in cardiac surgery to improve patient care. The aim of the present study was to evaluate the effect of OFA on post-operative morphine consumption and the post-operative course.
methodsAfter retrospectively registering to clinicaltrial.gov (NCT03816592), we performed a retrospective matched cohort study (1:1) on cardiac surgery patients with cardiopulmonary bypass between 2018 and 2019. Patients were divided into two groups: OFA (lidocaine, dexamethasone and ketamine) or opioid anaesthesia (OA) (sufentanil). The main outcome was the total postoperative morphine consumption in the 48 h after surgery. Secondary outcomes were rescue analgesic use, a major adverse event composite endpoint, and ICU and hospital length of stay (LOS).
resultsOne hundred ten patients were matched (OFA: n = 55; OA: n = 55). On inclusion, demographic and surgical data for the OFA and OA groups were comparable. The total morphine consumption was higher in the OA group than in the OFA group (15 (6-34) vs 5 mg (2-18), p = 0.001). The pain score during the first 48 post-operative hours did not differ between the two groups. Creatinine values did not differ on the first post-operative day (80 (IQR: 66-115) vs 77 mmol/l (IQR: 69-95), p = 0.284). Incidence of the composite endpoint was lower in the OFA group (25 patients (43%) vs 38 patients (68%), p = 0.021). The time to extubation and the ICU stays were shorter in the OFA group (3 (1-5) vs 5 (3-6) hours, p = 0.001 and 2 (1-3) vs 3 (2-5) days, p = 0.037).
conclusionThe use of OFA was associated with lower morphine consumption. OFA might be associated with shorter intubation time and ICU stays. Further randomized studies are needed to confirm these results.
trial registrationThis study was retrospectively registered to ct2 (identifier: NCT03816592 ) on January 25, 2019.
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