Evidence map›Paper›PMID 31366164›Full record

ArticleAntibiotics (Basel, Switzerland)2019

Cytokine Expression Patterns and Single Nucleotide Polymorphisms (SNPs) in Patients with Chronic Borreliosis.

Tabea M Hein, Philip Sander, Anwar Giryes, Jan-Olaf Reinhardt, Josef Hoegel, E Marion Schneider

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Tabea M HeinDivision of Experimental Anesthesiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Philip SanderDivision of Experimental Anesthesiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Anwar GiryesSwiss Medical Clinic AG, Grütstrasse 55, CH-8802 Kilchberg, Switzerland.
Jan-Olaf ReinhardtPractice for General Medicine, Sports Medicine, and Endocrinology, Leopoldstraße 17, 75172 Pforzheim, Germany.
Josef HoegelInstitute of Human Genetics, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
E Marion SchneiderDivision of Experimental Anesthesiology, University Hospital Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany. marion.schneider@uni-ulm.de.
University Hospital Ulm · DEPforzheim University of Applied Sciences · DESanatorium Kilchberg · CHUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Genetically based hyperinflammation may play a role in pathogen defense. We here questioned whether alterations in circulating monocytes/macrophages, inflammatory biomarkers and a functional SNP (single nucleotide polymorphisms) of the Interleukin-6 (IL-6) promotor might play a role in patients with persistent, and treatment resistant borreliosis. (2) Methods: Leukocyte subpopulations were studied by flow cytometry; plasma cytokines were determined by a chemiluminescence based ELISA (Immulite

Indexed as

CD163IL-1βIL-6IL-6 promotor SNP rs1800795IL-8Lyme borreliosispathogenspersisterspro-inflammatory cytokinesTNF-α

Identifiers

PMID31366164
PMCPMC6784230
OpenAlexW2965974198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.