Evidence map›Paper›PMID 31366051›Full record

ArticleInternational journal of molecular sciences2019

A Low Molecular Weight Hyaluronic Acid Derivative Accelerates Excisional Wound Healing by Modulating Pro-Inflammation, Promoting Epithelialization and Neovascularization, and Remodeling Collagen.

Yin Gao, Yao Sun, Hao Yang, Pengyu Qiu, Zhongcheng Cong, Yifang Zou, Liu Song, Jianfeng Guo, Tassos P Anastassiades

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 82 citations in OpenAlex.

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  8. Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.Journal of microbiology and biotechnology · 2025
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  16. Pleiotropic Potential ofMolecules (Basel, Switzerland) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yin GaoKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.ORCID 0000-0002-0763-0254
Yao SunSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.ORCID 0000-0002-6308-0111
Hao YangSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Pengyu QiuKey Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
Zhongcheng CongSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Yifang ZouSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Liu SongSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Jianfeng GuoSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. jguo@jlu.edu.cn.ORCID 0000-0002-2893-912X
Tassos P AnastassiadesDepartments of Medicine (Div. of Rheumatology), and of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.ORCID 0000-0002-5805-0364
Jilin University · CNQueen's University · CA

Funding

Department of Science and Technology of Jilin Province 20170520046JH, 20170520034JHEducation Department of Jilin Province JJKH20190099KJ, JJKH20180174KJFundamental Research Funds for the Central Universities, China N/AJilin Province Development and Reform Commission 2019C049-9National Natural Science Foundation of China 31700713
6 · The paper itself

Abstract

Recent knowledge of the cellular and molecular mechanisms underlying cutaneous wound healing has advanced the development of medical products. However, patients still suffer from the failure of current treatments, due to the complexity of healing process and thus novel therapeutic approaches are urgently needed. Previously, our laboratories produced a range of low molecular weight hyaluronic acid (LMW-HA) fragments, where a proportion of the glucosamine moieties were chemically N-acyl substituted. Specifically,

Indexed as

Neovascularization, PhysiologicRe-EpithelializationAnimalsAnti-Inflammatory AgentsCollagenHumansHuman Umbilical Vein Endothelial CellsHyaluronic AcidMacrophagesMaleRatsRats, WistarAnti-Inflammatory AgentsCollagenHyaluronic Acidangiogenesisanti-inflammationhyaluronanlymphangiogenesisN-butyrylation

Identifiers

PMID31366051
PMCPMC6695899
OpenAlexW2964605637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.