Evidence map›Paper›PMID 31365871›Full record

ArticleCell reports2019

Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish.

Andrés Sanz-Morejón, Ana B García-Redondo, Hanna Reuter, Inês J Marques, Thomas Bates, María Galardi-Castilla, Andreas Große, Steffi Manig, Xavier Langa, Alexander Ernst and 8 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
  2. Article
  3. Immune modulation promotes heart regeneration through macrophage and Granulin functions in medaka.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Immune-mediated cardiac development and regeneration.Seminars in cell & developmental biology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. ptx3aCell reports · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Andrés Sanz-MorejónInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Ana B García-RedondoCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain; Department of Pharmacology, Universidad Autónoma de Madrid, IIS-Hospital La Paz, Ciber de Enfermedades Cardiovasculares, 28029 Madrid, Spain.
Hanna ReuterLeibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.
Inês J MarquesInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Thomas BatesLeibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.
María Galardi-CastillaCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Andreas GroßeLeibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.
Steffi ManigLeibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.
Xavier LangaInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Alexander ErnstInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Indre PiragyteInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Marius-Alexandru BotosInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland.
Juan Manuel González-RosaCentro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain.
Marta Ruiz-OrtegaCellular Biology in Renal Diseases Laboratory, IIS-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain.
Ana M BrionesDepartment of Pharmacology, Universidad Autónoma de Madrid, IIS-Hospital La Paz, Ciber de Enfermedades Cardiovasculares, 28029 Madrid, Spain.
Mercedes SalaicesDepartment of Pharmacology, Universidad Autónoma de Madrid, IIS-Hospital La Paz, Ciber de Enfermedades Cardiovasculares, 28029 Madrid, Spain.
Christoph EnglertLeibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany; Institute of Biochemistry and Biophysics, Friedrich-Schiller-Universität, 07743 Jena, Germany.
Nadia MercaderInstitute of Anatomy, University of Bern, 3012 Bern, Switzerland; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain. Electronic address: nadia.mercader@ana.unibe.ch.
University of Bern · CHLeibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DESpanish National Centre for Cardiovascular Research · ESUniversidad Autónoma de Madrid · ESHospital Universitario Fundación Jiménez Díaz · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ regeneration is preceded by the recruitment of innate immune cells, which play an active role during repair and regrowth. Here, we studied macrophage subtypes during organ regeneration in the zebrafish, an animal model with a high regenerative capacity. We identified a macrophage subpopulation expressing Wilms tumor 1b (wt1b), which accumulates within regenerating tissues. This wt1b

Indexed as

RegenerationAnimal FinsAnimalsHeartMacrophagesWT1 ProteinsZebrafishZebrafish ProteinsWT1 ProteinsZebrafish Proteinsfin regenerationheart regenerationmacrophagesWilms tumor 1bzebrafish

Identifiers

PMID31365871
PMCPMC6685527
OpenAlexW2966671620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.