Evidence map›Paper›PMID 31365863›Full record

ArticleCell reports2019

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice.

Rune Rasmussen, Eric Nicholas, Nicolas Caesar Petersen, Andrea Grostøl Dietz, Qiwu Xu, Qian Sun, Maiken Nedergaard

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 82 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Astrocytes Regulate Brain State Transitions.Neurochemical research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Astrocyte: Metabolic Hub of the Brain.Cold Spring Harbor perspectives in biology · 2024
    Review
  12. Article
  13. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  14. Review
  15. Article
  16. Local extracellular KProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Rune RasmussenCenter for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: runerasmussen@dandrite.au.dk.
Eric NicholasCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Nicolas Caesar PetersenCenter for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Andrea Grostøl DietzCenter for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark.
Qiwu XuCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Qian SunCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Maiken NedergaardCenter for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: maiken_nedergaard@urmc.rochester.edu.
University of Rochester Medical Center · USUniversity of Copenhagen · DK

Funding

Para-Vascular Basis of Small Vessel DiseaseR01NS100366 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2016 to 2020
$3.8M
Characterizing the glymphatic peri-vascular connectome and its disruption in ADRF1AG053991 · NIA · YALE UNIVERSITY · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2016 to 2016
$3.4M
Age and AD related bottlenecks in glymphatic-lymphatic waste transportRF1AG057575 · NIA · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2017 to 2017
$3.2M
Capillary hyperemia in white matter: Novel mechanistic insight and effect of hypertension and agingRF1NS110049 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN, WAN, JIANDI · 2018 to 2018
$2.9M
The glymphatic system, a new concept in glia biologyR01NS078304 · NINDS · UNIVERSITY OF ROCHESTER · PI NEDERGAARD, MAIKEN · 2012 to 2016
$1.7M
Glymphatic function in a transgenic rat model of Alzheimer's diseaseR01AG048769 · NIA · UNIVERSITY OF ROCHESTER · PI BENVENISTE, HELENE D, NEDERGAARD, MAIKEN · 2014 to 2018
$1.4M
NIA NIH HHS R01 AG048769NIA NIH HHS RF1 AG053991NIA NIH HHS RF1 AG057575NINDS NIH HHS R01 NS078304NINDS NIH HHS R01 NS100366NINDS NIH HHS RF1 NS110049
6 · The paper itself

Abstract

Brain state fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked the dynamics of cortical extracellular K

Indexed as

Behavior, AnimalWakefulnessAnimalsCations, MonovalentCerebral CortexMicePotassiumCations, MonovalentPotassiumarousalcortical stateextracellular ionsgain modulationlocomotionmotor cortexpotassiumvisual cortex

Identifiers

PMID31365863
PMCPMC6790006
OpenAlexW2964464716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.