Evidence map›Paper›PMID 31365858›Full record

ArticleCell reports2019

Monocytes Acquire the Ability to Prime Tissue-Resident T Cells via IL-10-Mediated TGF-β Release.

Elizabeth A Thompson, Patricia A Darrah, Kathryn E Foulds, Elena Hoffer, Alayna Caffrey-Carr, Sophie Norenstedt, Leif Perbeck, Robert A Seder, Ross M Kedl, Karin Loré

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 65 citations in OpenAlex.

  1. HLA-DRAllergy · 2025
    Trial
  2. Article
  3. Review
  4. Origins of CD8 tissue resident memory.Frontiers in immunology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Monocyte-derived TGF-β shapes memory CD8+ T cells.Cellular & molecular immunology · 2025
    Article
  9. Review
  10. Article
  11. Expansion of CD103Frontiers in immunology · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Functional Diversity of Memory CD8 T Cells is Spatiotemporally Imprinted.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Elizabeth A ThompsonDepartment of Medicine, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm 17164, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden. Electronic address: ethomp58@jhmi.edu.
Patricia A DarrahVaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
Kathryn E FouldsVaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
Elena HofferDepartment of Medicine, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm 17164, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Alayna Caffrey-CarrDepartment of Immunology & Microbiology, University of Colorado Denver, Aurora, CO 80045, USA.
Sophie NorenstedtKirurgkliniken, Capio St Görans Sjukhus, Stockholm 11281, Sweden.
Leif PerbeckDepartment of Surgery, Karolinska University Hospital, Solna 17176, Sweden.
Robert A SederVaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.
Ross M KedlDepartment of Immunology & Microbiology, University of Colorado Denver, Aurora, CO 80045, USA.
Karin LoréDepartment of Medicine, Division of Immunology and Allergy, Karolinska Institutet and Karolinska University Hospital, Stockholm 17164, Sweden; Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden. Electronic address: karin.lore@ki.se.
National Institutes of Health · USKarolinska Institutet · SEKarolinska University Hospital · SEUniversity of Colorado Denver · USSaint Göran Hospital · SE

Funding

Non-Human Primate CoreZICAI005103 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FOULDS, KATHRYN · 2009 to 2025
$22.7M
Transcriptional regulation of vaccine-elicited and infection-elicited CD8+ T cell responsesR01AI066121 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Ross M Kedl · 2007 to 2026
$7.1M
Combined TLR/CD40-agonist induced CD8+ T cell memoryR01AI068777 · NIAID · UNIVERSITY OF COLORADO DENVER · PI KEDL, ROSS M · 2006 to 2009
$1.5M
NIAID NIH HHS R01 AI066121NIAID NIH HHS R01 AI068777
6 · The paper itself

Abstract

Using non-human primates (NHPs), mice, and human primary cells, we found a role for interleukin-10 (IL-10) in the upregulation of the tissue-resident memory T cell (T

Indexed as

Immunologic MemoryAnimalsAntigens, CDHumansIntegrin alpha ChainsInterleukin-10Macaca mulattaMiceMonocytesT-LymphocytesTransforming Growth Factor betaalpha E integrinsAntigens, CDIL10 protein, humanIntegrin alpha ChainsInterleukin-10Transforming Growth Factor betaanti-CD40IL-10monocytenon-human primateT cellTGF-betatissue-resident memory T cellstoll-like receptorTRMvaccine

Identifiers

PMID31365858
PMCPMC6825402
OpenAlexW2964645640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.