Evidence map›Paper›PMID 31365836›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Mitophagy protects against statin-mediated skeletal muscle toxicity.

Mridula Ramesh, Juliane C Campos, Pamela Lee, Yang Song, Genaro Hernandez, Jon Sin, Kyle C Tucker, Hannaneh Saadaeijahromi, Michael Gurney, Julio C B Ferreira and 1 more

Expression of concernOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Ubiquitin Ligases in Longevity and Aging Skeletal Muscle.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Mridula Ramesh *Donald P. Shiley BioScience Center, San Diego State University, San Diego, California, USA.
Juliane C Campos *Cedars-Sinai Medical Center, Los Angeles, California, USA.
Pamela LeeDonald P. Shiley BioScience Center, San Diego State University, San Diego, California, USA.
Yang SongCedars-Sinai Medical Center, Los Angeles, California, USA.
Genaro HernandezDonald P. Shiley BioScience Center, San Diego State University, San Diego, California, USA.
Jon SinCedars-Sinai Medical Center, Los Angeles, California, USA.
Kyle C TuckerCedars-Sinai Medical Center, Los Angeles, California, USA.
Hannaneh SaadaeijahromiCedars-Sinai Medical Center, Los Angeles, California, USA.
Michael GurneyDonald P. Shiley BioScience Center, San Diego State University, San Diego, California, USA.
Julio C B FerreiraInstitute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
Allen M AndresCedars-Sinai Medical Center, Los Angeles, California, USA.
Cedars-Sinai Medical Center · USSan Diego State University · USUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The deleterious effects of statins on skeletal muscle are well known, but the mechanism associated with these effects remains unresolved. Statins are associated with mitochondrial damage, which may contribute to muscle myopathy. Here we demonstrate that simvastatin induces mitophagy in skeletal muscle cells and hypothesized that attenuating this process by silencing the mitophagy adapter p62/sequestosome-1 (SQSTM1) might mitigate myotoxicity. Surprisingly, silencing p62/SQSTM1 in differentiated C2C12 muscle cells exacerbated rather than attenuated myotoxicity. This inhibition of mitophagy in the face of statin challenge correlated with increased release of cytochrome

Indexed as

AnimalsCaspase 3Cell LineCytochromes cHydroxymethylglutaryl-CoA Reductase InhibitorsL-Lactate DehydrogenaseMice, KnockoutMitophagyMuscle, SkeletalMyoblastsRNA InterferenceSequestosome-1 ProteinSimvastatinUbiquitin-Protein LigasesCaspase 3Cytochromes cHydroxymethylglutaryl-CoA Reductase InhibitorsL-Lactate Dehydrogenaseparkin proteinSequestosome-1 ProteinSimvastatinSqstm1 protein, mouseUbiquitin-Protein Ligasesmitochondriamyopathysimvastatin

Identifiers

PMID31365836
PMCPMC6902735
OpenAlexW2965260176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.