Evidence map›Paper›PMID 31365819›Full record

ReviewBioconjugate chemistry2020

Squaraine Dyes: Molecular Design for Different Applications and Remaining Challenges.

Kristina Ilina, William M MacCuaig, Matthew Laramie, Jannatun N Jeouty, Lacey R McNally, Maged Henary

Abstract readReview
In one paragraph

Review in Bioconjugate chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Synthesis, Structure, and Thin Film Optical Properties of a Chiral Benzothiazole-Derived Squaraine.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Fluorescent Albumin-BindingInternational journal of molecular sciences · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristina IlinaDepartment of Chemistry, Petit Science Center , Georgia State University , 100 Piedmont Avenue SE , Atlanta , Georgia 30303 , United States.
William M MacCuaigDepartment of Bioengineering, Stephenson Cancer Center , University of Oklahoma , 173 Felgar Street , Norman , Oklahoma 73019 , United States.
Matthew LaramieDepartment of Chemistry, Petit Science Center , Georgia State University , 100 Piedmont Avenue SE , Atlanta , Georgia 30303 , United States.
Jannatun N JeoutyDepartment of Chemistry, Petit Science Center , Georgia State University , 100 Piedmont Avenue SE , Atlanta , Georgia 30303 , United States.
Lacey R McNallyDepartment of Bioengineering, Stephenson Cancer Center , University of Oklahoma , 173 Felgar Street , Norman , Oklahoma 73019 , United States.
Maged HenaryDepartment of Chemistry, Petit Science Center , Georgia State University , 100 Piedmont Avenue SE , Atlanta , Georgia 30303 , United States.ORCID 0000-0002-6475-0156

Funding

Image-Guided Drug Delivery for Pancreatic Neuroendocrine Tumor.R01EB022230 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHOI, HAK SOO, HENARY, MAGED M · 2017 to 2020
$3.6M
Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Non-Invasive Detection of Tumor Extracellular pH using Multispectral Optoacoustic TomographyR01CA205941 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2021
$1.7M
Theranostic Nanoparticles For Detection and Treatment of Pancreatic CancerR01EB020125 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA205941NCI NIH HHS R01 CA212350NIBIB NIH HHS R01 EB020125NIBIB NIH HHS R01 EB022230
6 · The paper itself

Abstract

Squaraine dyes are a class of organic dyes with strong and narrow absorption bands in the near-infrared. Despite high molar absorptivities and fluorescence quantum yields, these dyes have been less explored than other dye scaffolds due to their susceptibility to nucleophilic attack. Recent strategies in probe design including encapsulation, conjugation to biomolecules, and new synthetic modifications have seen squaraine dyes emerging into the forefront of biomedical imaging and other applications. Herein, we provide a concise overview of (1) the synthesis of symmetrical and unsymmetrical squaraine dyes, (2) the relationship between structure and photophysical properties of squaraine dyes, and (3) current applications of squaraine dyes in the literature. Given the recent successes at overcoming the limitations of squaraine dyes, they show high potential in biological imaging, in photodynamic and photothermal therapies, and as molecular sensors.

Indexed as

AnimalsChemistry Techniques, SyntheticCyclobutanesFluorescent DyesHumansOptical ImagingPhenolsPhotochemotherapyPhotothermal TherapyCyclobutanesFluorescent DyesPhenolssquaraine

Identifiers

PMID31365819
PMCPMC7845514

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.