ArticleJournal of experimental botany2019
A MIF-like effector suppresses plant immunity and facilitates nematode parasitism by interacting with plant annexins.
Article in Journal of experimental botany, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 83 citations in OpenAlex.
- Comprehensive Analysis of Annexin Family fromPlants (Basel, Switzerland) · 2026Article
- Status and advancement of root-knot nematode management strategies and the emerging CRISPR/Cas biotechnology application.Functional & integrative genomics · 2026Review
- Molecular mimicry and trafficking of peptide effectors in sedentary nematodes: emerging drivers of feeding site formation and host signaling hijack.Crop health · 2026Review
- Plant Biotic Stress: Tools and Techniques for Crop Protection.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Metagenomic analysis suggests that tomato root-knot nematode infestation disrupts rhizosphere microbial networks, consistent with reduced disease suppression.Frontiers in microbiology · 2026Article
- Annexin D1 and KIN29: Calcium-activated module promotes potyvirus infection.Plant physiology · 2025Article
- Discovery of an SQS-PSY Domain-Containing Protein inInternational journal of molecular sciences · 2025Article
- Article
- NRPS-like ATRR in Plant-Parasitic Nematodes Involved in Glycine Betaine Metabolism to Promote Parasitism.International journal of molecular sciences · 2024Article
- A critical review on bioaerosols-dispersal of crop pathogenic microorganisms and their impact on crop yield.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Review
- The root-knot nematode effector Mi2G02 hijacks a host plant trihelix transcription factor to promote nematode parasitism.Plant communications · 2024Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Comprehensive analysis of annexin gene family and its expression in response to branching architecture and salt stress in crape myrtle.BMC plant biology · 2024Article
- The Wheat AnnexinInternational journal of molecular sciences · 2023Article
- Counter-attack of biocontrol agents: Environmentally benign Approaches against Root-knot nematodes (Heliyon · 2023Review
- Review
- MIF-like domain containing protein orchestrates cellular differentiation and virulence in the fungal pathogeniScience · 2023Article
- Multiomics analysis reveals the molecular mechanisms underlying virulence in Rhizoctonia and jasmonic acid-mediated resistance in Tartary buckwheat (Fagopyrum tataricum).The Plant cell · 2023Article
- Transcriptome Sequencing and WGCNA Reveal Key Genes in Response to Leaf Blight in Poplar.International journal of molecular sciences · 2023Article
- Single Nematode Transcriptomic Analysis, Using Long-Read Technology, Reveals Two Novel Virulence Gene Candidates in the Soybean Cyst Nematode,International journal of molecular sciences · 2023Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-parasitic nematodes secrete numerous effectors to facilitate parasitism, but detailed functions of nematode effectors and their plant targets remain largely unknown. Here, we characterized four macrophage migration inhibitory factors (MIFs) in Meloidogyne incognita resembling the MIFs secreted by human and animal parasites. Transcriptional data showed MiMIFs are up-regulated in parasitism. Immunolocalization provided evidence that MiMIF proteins are secreted from the nematode hypodermis to the parasite surface, detected in plant tissues and giant cells. In planta MiMIFs RNA interference in Arabidopsis decreased infection and nematode reproduction. Transient expression of MiMIF-2 could suppress Bax- and RBP1/Gpa2-induced cell death. MiMIF-2 ectopic expression led to higher levels of Arabidopsis susceptibility, suppressed immune responses triggered by flg22, and impaired [Ca2+]cyt influx induced by H2O2. The immunoprecipitation of MiMIF-2-interacting proteins, followed by co-immunoprecipitation and bimolecular fluorescence complementation validations, revealed specific interactions between MiMIF-2 and two Arabidopsis annexins, AnnAt1 and AnnAt4, involved in the transport of calcium ions, stress responses, and signal transduction. Suppression of expression or overexpression of these annexins modified nematode infection. Our results provide functional evidence that nematode effectors secreted from hypodermis to the parasite cuticle surface target host proteins and M. incognita uses MiMIFs to promote parasitism by interfering with the annexin-mediated plant immune responses.
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