ArticleJournal of applied oral science : revista FOB2019
The role of visfatin levels in gingival crevicular fluid as a potential biomarker in the relationship between obesity and periodontal disease.
Article in Journal of applied oral science : revista FOB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 8 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 8 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Comparison of visfatin levels before and after non-surgical periodontal therapy: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Pooled it
- Systemic benefits of periodontal therapy in patients with obesity and periodontitis: a systematic review.Brazilian oral research · 2024Pooled it
- The Potential of Gingival Crevicular Fluid as a Tool for Molecular Diagnosis: A Systematic Review.BioMed research international · 2024Pooled it
- Periodontitis is associated with the increased levels of visfatin: a meta-analysis.BMC oral health · 2023Pooled it
- Effect of non-surgical periodontal treatment on cytokines/adipocytokines levels among periodontitis patients with or without obesity: a systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Pooled it
- Association between clinical measures of gingival inflammation and obesity in adults: systematic review and meta-analyses.Clinical oral investigations · 2021Pooled it
- The Prevalence of the Periodontal PathogenClinical, cosmetic and investigational dentistry · 2025Article
- Article
- Effect of non-surgical periodontal treatment on visfatin and chemerin concentration in the gingival crevicular fluid.Odontology · 2024Article
- Retinol-Binding Protein 4 and Visfatin Levels in Patients with Periodontitis and Obesity/Overweight: A Systematic Review and Meta-Analysis.Current issues in molecular biology · 2023Review
- Association between lipid metabolism and periodontitis in obese patients: a cross-sectional study.BMC endocrine disorders · 2023Article
- Is periodontal inflamed surface area associated with serum and salivary levels of IL-1β, visfatin, and omentin-1 in overweight/obese patients?Clinical oral investigations · 2022Article
- Correlation of salivary visfatin levels in obese and NON-OBESE population with periodontal status.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesVisfatin is an adipokine that plays an important role in immune functions as a growth factor, enzyme, and pro-inflammatory mediator. We aimed to determine the levels of visfatin, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF) in both obese/non-obese patients, with/without generalized chronic periodontitis (GCP). METHODOLOGY: Patients were categorized as obese (O) (n=31) or non-obese (nO) (n=19). Groups were divided into four subgroups according to periodontal conditions: (1) periodontally healthy without obesity (nO-Ctrl); (2) GCP without obesity (nO-CP); (3) periodontally healthy with obesity (O-Ctrl); and (4) GCP with obesity (O-CP). Demographic variables, anthropometric and laboratory data were recorded. Periodontal parameters were measured at baseline and 3rd months after either non-surgical periodontal treatment or calorie -restricted diet therapy. At the same time, GCF samples were taken from patients to analyze TNF-alpha, IL-6,and visfatin levels.
resultsPeriodontal parameters were significantly higher in the O group than in the nO group (P<0.05). IL-6 levels were higher in the O group than in the nO group (P<0.001). The visfatin levels of the obese patients were reduceddecreased following the treatments (P<0.05). Cholesterol levels were higher in the O group than in the nO groups (P<0.05). IL-6 levels were higher in O-CP and O-Ctrl groups than in the nO-Ctrl group (P<0.05). Compared to the other groups, visfatin levels were significantly higher in the O-CP group but decreased following treatment (P<0.05).
conclusionsOur findings suggest that visfatin and IL-6 levels in GCF are associated with the pathogenesis of obesity and periodontitis. Within the limits of this study, we considered that there might be an association between the lipid profile and periodontitis on systemically healthy individuals.
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