ArticleJournal of neurophysiology2019
Eating "junk food" has opposite effects on intrinsic excitability of nucleus accumbens core neurons in obesity-susceptible versus -resistant rats.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Application of Machine Learning Models to Identify Differences in Neural Electrophysiological Properties Across Estrous Cycle Phases.Neuroinformatics · 2026Article
- Divergent Roles of Nucleus Accumbens D1- and D2-MSNs in Regulating Hedonic Feeding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- APOE-ε4 genotype and western diet synergistically aggravate synaptic dysfunction in Alzheimer's disease via D-serine disruption.Alzheimer's research & therapy · 2026Article
- Weight Loss After Obesity Disrupts Cognitive Flexibility Through Reinforcement Learning Strategies.Obesity (Silver Spring, Md.) · 2026Article
- Ultra-processed food consumption affects structural integrity of feeding-related brain regions independent of and via adiposity.npj metabolic health and disease · 2025Article
- Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens DBiological psychiatry · 2024Article
- Sex Differences in the Relationship Between Nucleus Accumbens Volume and Youth Tobacco or Marijuana Use Following Stressful Life Events.Journal of mental health & clinical psychology · 2024Article
- Melanin-concentrating hormone attenuates the hedonic feeding induced by orexin-A in the ventral tegmental area of high-fat diet male mice.Frontiers in nutrition · 2024Article
- Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment.Neuropharmacology · 2024Article
- Short- and Long-Term High-Fat Diet Exposure Differentially Alters Phasic and Tonic GABAergic Signaling onto Lateral Orbitofrontal Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Cocaine-induced plasticity, motivation, and cue responsivity do not differ in obesity-prone vs obesity-resistant rats; implications for food addiction.Psychopharmacology · 2023Article
- Transient effects of junk food on NAc core MSN excitability and glutamatergic transmission in obesity-prone female rats.Obesity (Silver Spring, Md.) · 2023Article
- Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.Journal of neurochemistry · 2023Article
- Neuroimaging and modulation in obesity and diabetes research: 10th anniversary meeting.International journal of obesity (2005) · 2022Review
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Sex specific effects of "junk-food" diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Why Dieters Succeed or Fail: The Relationship Between Reward and Punishment Sensitivity and Restrained Eating and Dieting Success.Frontiers in psychology · 2021Article
- Metaplasticity in the Ventral Pallidum as a Potential Marker for the Propensity to Gain Weight in Chronic High-Calorie Diet.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The nucleus accumbens (NAc) plays critical roles in motivated behaviors, including food seeking and feeding. Differences in NAc function contribute to overeating that drives obesity, but the underlying mechanisms are poorly understood. In addition, there is a fair degree of variation in individual susceptibility versus resistance to obesity that is due in part to differences in NAc function. For example, using selectively bred obesity-prone and obesity-resistant rats, we have found that excitability of medium spiny neurons (MSNs) within the NAc core is enhanced in obesity-prone versus -resistant populations, before any diet manipulation. However, it is unknown whether consumption of sugary, fatty "junk food" alters MSN excitability. Here whole cell patch-clamp recordings were conducted to examine MSN intrinsic excitability in adult male obesity-prone and obesity-resistant rats with and without exposure to a sugary, fatty junk food diet. We replicated our initial finding that basal excitability is enhanced in obesity-prone versus obesity-resistant rats and determined that this is due to a lower fast transient potassium current (
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