Trial reportAmerican journal of respiratory and critical care medicine2019
Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial.
Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01812447 (A Prospective, Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Spiration® Valve System for the Single Lobe Treatment of Severe Emphysema), which is not on this map. Cited by 68 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Controlled Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the Spiration® Valve System for the Single Lobe Treatment of Severe Emphysema
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 171 citations in OpenAlex.
- Pooled it
- Expert Statement: Pneumothorax Associated with One-Way Valve Therapy for Emphysema: 2020 Update.Respiration; international review of thoracic diseasesGuideline
- Sustained Clinical Benefits of Spiration Valve System in Patients with Severe Emphysema: 24-Month Follow-Up of EMPROVE.Annals of the American Thoracic Society · 2024Trial
- Advancing Precision Approaches to Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2026Review
- Connecting the dots: historical perspective on lung volume reduction.Journal of thoracic disease · 2026Review
- Observational
- Endobronchial Valves for Bronchoscopic Lung Volume Reduction in Severe Emphysema: A Reversible and Non-Surgical Treatment for Patients Who May or May Not Be Candidates for Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Review
- Endobronchial valves for severe air leak in critically ill children with necrotizing pneumonia requiring extracorporeal membrane oxygenation.Perfusion · 2026Article
- Bronchoscopic endobronchial valves.Breathe (Sheffield, England) · 2026Review
- Stem cell therapies for biological repair in osteonecrosis: advances, challenges, and clinical insights.Frontiers in medicine · 2026Review
- Endoscopic Lung Volume Reduction with Valves Improves Cardiovascular Adaptability and 6-MWT Performance in Severely Limited COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Article
- Endobronchial Valve Therapy vs Lung Volume Reduction Surgery in the United States.The Annals of thoracic surgery · 2025Article
- Article
- Risk Factors for Pneumothorax After Treatment With Endobronchial Valves: A Cohort Study.Respirology (Carlton, Vic.) · 2025Article
- Article
- Bronchoscopic Lung Volume Reduction: Effect on Symptoms and Lung Function in Patients With Emphysema Who Qualify for Lung Transplant.CHEST pulmonary · 2025Article
- The Emerging Biomarkers in Chronic Obstructive Pulmonary Disease: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Bronchoscopic Lung Volume Reduction: A Narrative Review and Proposal for the Inclusion Criteria.Journal of clinical medicine · 2025Review
- The Value of a High-Volume Bronchoscopic Lung Volume Reduction Program for Patients With Severe Emphysema.CHEST pulmonary · 2025Article
- Outcome and safety 90 days after combined airway valve treatment of the right upper and middle lobes in patients with severe pulmonary emphysema.Respiratory research · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on byReply to Jain2020
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Authors and funding
36 authors at 20 institutions in 2 countries.
Gerard J CrinerLewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.ORCID 0000-0003-1267-3483
Antoine DelageInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Hôpital Laval, Quebec, Quebec, Canada.
Kirk VoelkerSarasota Memorial Hospital, Sarasota, Florida.
D Kyle HogarthUniversity of Chicago Medical Center, Chicago, Illinois.
Adnan MajidBeth Israel Deaconess Medical Center, Boston, Massachusetts.
Michael ZgodaCarolinas Medical Center (Atrium Health), Charlotte, North Carolina.
Donald R LazarusMichael E. DeBakey Veterans Affairs (VA) Medical Center, Dallas, Texas.
Roberto CasalMichael E. DeBakey Veterans Affairs (VA) Medical Center, Dallas, Texas.
Sadia B BenzaquenUniversity of Cincinnati Hospital, Cincinnati, Ohio.
Robert C HolladayLouisiana State University Health Sciences Center, Shreveport, Louisiana.
Adam WellikoffLouisiana State University Health Sciences Center, Shreveport, Louisiana.
Karel CaleroTampa General Hospital, University South Florida, Tampa, Florida.
Mark J RumbakTampa General Hospital, University South Florida, Tampa, Florida.
Paul R BrancaUniversity of Tennessee Medical Center, Knoxville, Tennessee.
Muhanned Abu-HijlehUniversity of Texas Southwestern Medical Center at Dallas, Dallas, Texas.
Jorge M MalleaMayo Clinic Florida, Jacksonville, Florida.
Ravi KalhanNorthwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0003-2443-0876
Ashutosh SachdevaUniversity of Maryland Medical Center, Baltimore, Maryland.
C Matthew KinseyUniversity of Vermont Medical Center, Burlington, Vermont.
Carla R LambLahey Hospital & Medical Center, Burlington, Massachusetts.
Michael F ReedPenn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
Wissam B AbouzgheibCooper University Hospital, Camden, New Jersey.
Phillip V KaplanDetroit Clinical Research Center, Beaumont Botsford Hospital, Farmington Hills, Michigan.
Gregory X MarrujoKaiser Permanente Riverside Medical Center, Riverside, California.
David W JohnstoneFroedtert Hospital, Medical College of Wisconsin, Milwaukee, Wisconsin.
Mario G GasparriFroedtert Hospital, Medical College of Wisconsin, Milwaukee, Wisconsin.
Arturo A MeadeSparks Regional Medical Center, Fort Smith, Arkansas.
Christopher A HergottCumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Chakravarthy ReddyUniversity of Utah Health Sciences, Salt Lake City, Utah.
Richard A MularskiKaiser Permanente Northwest, Portland, Oregon.
Amy Hajari CasePiedmont Hospital, Atlanta, Georgia.
Samir S MakaniUniversity of California Medical Center at San Diego, San Diego, California.
Ray W ShepherdVirginia Commonwealth University, Richmond, Virginia.
Benson ChenCalifornia Pacific Medical Center, San Francisco, California; and.
Gregory E HoltMiami VA Healthcare System, Miami, Florida.
Simon MartelInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Hôpital Laval, Quebec, Quebec, Canada.
Froedtert Hospital · USInstitut universitaire de cardiologie et de pneumologie de Québec · CALouisiana State University Health Sciences Center Shreveport · USMichael E. DeBakey VA Medical Center · USTampa General Hospital · USBeth Israel Deaconess Medical Center · USBotsford Hospital · USCalifornia Pacific Medical Center · USCarolinas Medical Center · USCooper University Hospital · USJacksonville College · USKaiser Permanente · USKaiser Permanente Riverside Medical Center · USLahey Medical Center · USMiami VA Healthcare System · USNorthwestern University · USPenn State Milton S. Hershey Medical Center · USPiedmont Atlanta Hospital · USRegional Medical Center · USSarasota Memorial Hospital · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MNorthwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8MUsing Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Kristen Pierce · 2018 to 2026
$24.9MNCATS NIH HHS UL1 TR001102NCATS NIH HHS UL1 TR001422NIGMS NIH HHS P20 GM125498
Abstract
PubMed holds no abstract for this paper.
Indexed as
Prostheses and ImplantsAgedBronchiFemaleForced Expiratory VolumeHumansInhalationLungMalePulmonary EmphysemaTreatment Outcomechronic obstructive pulmonary diseaseFEVquality of life
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT01812447ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.