ArticleClinical and translational science2019
Continuous Monitoring Using a Wearable Device Detects Activity-Induced Heart Rate Changes After Administration of Amphetamine.
Article in Clinical and translational science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Vigilance and Well-Being in Daily Life: An Examination of Race Differences.Race and social problems · 2026Article
- Sleep efficiency is negatively associated with resting daytime heart rate in trauma-exposed premenopausal women.Physiological reports · 2025Article
- Implementing sensor-based digital health technologies in clinical trials: Key considerations from the eCOA Consortium.Clinical and translational science · 2024Review
- Recent Advances in the Wearable Devices for Monitoring and Management of Heart Failure.Reviews in cardiovascular medicine · 2024Review
- Review
- Digital technologies: Innovations that transform the face of drug development.Clinical and translational science · 2023Review
- Empowering drug development: Leveraging insights from imaging technologies to enable the advancement of digital health technologies.Clinical and translational science · 2023Review
- Wearable Electrocardiography for Physical Activity Monitoring: Definition of Validation Protocol and Automatic Classification.Biosensors · 2023Article
- Article
- Accuracy of Heart Rate and Respiratory Rate Measurements Using Two Types of Wearable Devices.Progress in rehabilitation medicine · 2022Article
- Remote Cardiac Rhythm Monitoring in the Era of Smart Wearables: Present Assets and Future Perspectives.Frontiers in cardiovascular medicine · 2022Review
- Detection of Clenbuterol-Induced Changes in Heart Rate Using At-Home Recorded Smartwatch Data: Randomized Controlled Trial.JMIR formative research · 2021Article
- Objective Behavioral Measures in Children before, during, and after the COVID-19 Lockdown in Israel.International journal of environmental research and public health · 2021Article
- Regulatory, Legal, and Market Aspects of Smart Wearables for Cardiac Monitoring.Sensors (Basel, Switzerland) · 2021Article
- [Research progress on wearable physiological parameter monitoring and its clinical applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Review
- Fit-for-Purpose Biometric Monitoring Technologies: Leveraging the Laboratory Biomarker Experience.Clinical and translational science · 2021Review
- Prediction of viral symptoms using wearable technology and artificial intelligence: A pilot study in healthcare workers.PloS one · 2021Article
- An Evaluation of Biometric Monitoring Technologies for Vital Signs in the Era of COVID-19.Clinical and translational science · 2020Review
- Remote Cardiac Safety Monitoring through the Lens of the FDA Biomarker Qualification Evidentiary Criteria Framework: A Case Study Analysis.Digital biomarkersReview
- Sensor technology for nursing research.Nursing outlookReview
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wearable digital devices offer potential advantages over traditional methods for the collection of health-related information, including continuous collection of dense data while study subjects are ambulatory or in remote settings. We assessed the utility of collecting continuous actigraphy and cardiac monitoring by deploying two US Food and Drug Administration (FDA) 510(k)-cleared devices in a phase I clinical trial of a novel compound, which included the use of an amphetamine challenge. The Phillips Actiwatch Spectrum Pro (Actiwatch) was used to assess mobility and sleep. The Preventice BodyGuardian (BodyGuardian) was used for monitoring heart rate (HR) and respiratory rate (RR), via single-lead electrocardiogram (ECG) recordings, together with physical activity. We measured data collection rates, compared device readouts with conventional measures, and monitored changes in HR measures during the amphetamine challenge. Completeness of data collection was good for the Actiwatch (96%) and lower for the BodyGuardian (80%). A good correlation was observed between device and in-clinic measures for HR (r = 0.99; P < 0.001), but was poor for RR (r = 0.39; P = 0.004). Manual reviews of selected ECG strips corresponding to HR measures below, within, and above the normal range were consistent with BodyGuardian measurements. The BodyGuardian device detected clear HR responses after amphetamine administration while subjects were physically active, whereas conventional measures collected at predefined timepoints while subjects were resting and supine did not. Wearable digital technology shows promise for monitoring human subjects for physiologic changes and pharmacologic responses, although fit-for-purpose evaluation and validation continues to be important prior to the wider deployment of these devices.
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