ArticleHuman brain mapping2019
Large-scale white matter network reorganization in posttraumatic stress disorder.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of Post-Traumatic Stress Disorder Duration on Volumetric and Microstructural Parameters of the Hippo-Campus, Amygdala, and Prefrontal Cortex: A Multiparametric Magnetic Resonance Imaging Study with Correlation Analysis.Journal of clinical medicine · 2025Article
- Cerebellar microstructural abnormalities in patients with somatic symptom disorders.BMC psychiatry · 2025Article
- Sensory alterations in post-traumatic stress disorder.Current opinion in neurobiology · 2024Review
- Resolving Heterogeneity in Posttraumatic Stress Disorder Using Individualized Structural Covariance Network Analysis.Depression and anxiety · 2024Article
- Graph theory-based analysis reveals neural anatomical network alterations in chronic post-traumatic stress disorder.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Study on the changes of Structural Covariance Network in post-traumatic stress disorder.Brain imaging and behavior · 2022Article
- Disrupted Brain Functional Network Topology in Essential Tremor Patients With Poor Sleep Quality.Frontiers in neuroscience · 2022Article
- DTI Connectometry Analysis Reveals White Matter Changes in Cognitively Impaired World Trade Center Responders at Midlife.Journal of Alzheimer's disease : JAD · 2022Article
- Disruption of the white matter structural network and its correlation with baseline progression rate in patients with sporadic amyotrophic lateral sclerosis.Translational neurodegeneration · 2021Article
- The dissociative subtype of posttraumatic stress disorder is associated with subcortical white matter network alterations.Brain imaging and behavior · 2021Article
- Altered Functional Network in Infants With Profound Bilateral Congenital Sensorineural Hearing Loss: A Graph Theory Analysis.Frontiers in neuroscience · 2021Article
- Disrupted Topological Organization in White Matter Networks in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2021Article
- Alterations of White Matter Network Properties in Patients With Functional Constipation.Frontiers in neurology · 2021Article
- Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms.Frontiers in human neuroscience · 2021Article
- Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia.Human brain mapping · 2020Article
- Mechanisms Underlying Unconscious Processing and Their Alterations in Post-traumatic Stress Disorder: Neuroimaging of Zero Monetary Outcomes Contextually Framed as "No Losses" vs. "No Gains".Frontiers in neuroscience · 2020Article
- Large-scale white matter network reorganization in posttraumatic stress disorder.Human brain mapping · 2019Article
- [Advances in the application of individualized white-matter functional networks in children and adolescents with attention-deficit/hyperactivity disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Recently, graph theoretical approaches applied to neuroimaging data have advanced understanding of the human brain connectome and its abnormalities in psychiatric disorders. However, little is known about the topological organization of brain white matter networks in posttraumatic stress disorder (PTSD). Seventy-six patients with PTSD and 76 age, gender, and years of education-matched trauma-exposed controls were studied after the 2008 Sichuan earthquake using diffusion tensor imaging and graph theoretical approaches. Topological properties of brain networks including global and nodal measurements and modularity were analyzed. At the global level, patients showed lower clustering coefficient (p = .016) and normalized characteristic path length (p = .035) compared with controls. At the nodal level, increased nodal centralities in left middle frontal gyrus, superior and inferior temporal gyrus and right inferior occipital gyrus were observed (p < .05, corrected for false-discovery rate). Modularity analysis revealed that PTSD patients had significantly increased inter-modular connections in the fronto-parietal module, fronto-striato-temporal module, and visual and default mode modules. These findings indicate a PTSD-related shift of white matter network topology toward randomization. This pattern was characterized by an increased global network integration, reflected by increased inter-modular connections with increased nodal centralities involving fronto-temporo-occipital regions. This study suggests that extremely stressful life experiences, when they lead to PTSD, are associated with large-scale brain white matter network topological reconfiguration at global, nodal, and modular levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.