ArticleHuman brain mapping2019
Cerebellar contribution to auditory feedback control of speech production: Evidence from patients with spinocerebellar ataxia.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Probing the role of left inferior frontal gyrus in vocal motor control: Evidence from TMS and causal inference analysis.iScience · 2026Article
- Sensorimotor Adaptation of Vocal Pitch Is Impaired in Cerebellar Ataxia.Journal of cognitive neuroscience · 2026Article
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- Investigating Cerebello-Cortical Networks With EEG: Advances and Future Challenges.Cerebellum (London, England) · 2026Review
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Phase-Specific Contributions and Interactions of the Left and Right Posterior Middle Temporal Gyri in Vocal Feedback Control: Evidence From Dual-Site TMS.Human brain mapping · 2025Article
- Sensorimotor adaptation of vocal pitch is severely impaired in cerebellar ataxia.bioRxiv : the preprint server for biology · 2025Article
- Bayesian inference of state feedback control parameters for fo perturbation responses in cerebellar ataxia.PLoS computational biology · 2024Article
- The Contributions of Pitch, Loudness, and Rate Control to Speech Naturalness in Cerebellar Ataxia.American journal of speech-language pathology · 2024Article
- EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia.Journal of clinical medicine · 2024Review
- Test-Retest Reliability of Behavioral Assays of Feedforward and Feedback Auditory-Motor Control of Voice and Articulation.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Effects of Low-Frequency Deep Brain Stimulation in Bilateral Zona Incerta for a Patient With Tremor and Cerebellar Ataxia.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Physiological Recordings of the Cerebellum in Movement Disorders.Cerebellum (London, England) · 2023Review
- Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation.Frontiers in neuroscience · 2023Article
- Neurophysiology of cerebellar ataxias and gait disorders.Clinical neurophysiology practice · 2023Review
- Aging-related decline in the neuromotor control of speech production: current and future.Frontiers in aging neuroscience · 2023Article
- Continuous theta burst stimulation over right cerebellum for speech impairment in Parkinson's disease: study protocol for a randomized, sham-controlled, clinical trial.Frontiers in aging neuroscience · 2023Article
- What Can Altered Auditory Feedback Paradigms Tell Us About Vocal Motor Control in Individuals With Voice Disorders?Perspectives of the ASHA special interest groups · 2022Article
- Assessing Ecologically Valid Methods of Auditory Feedback Measurement in Individuals With Typical Speech.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Musical abilities in children with developmental cerebellar anomalies.Frontiers in systems neuroscience · 2022Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The cerebellum has been implicated in the feedforward control of speech production. However, the role of the cerebellum in the feedback control of speech production remains unclear. To address this question, the present event-related potential study examined the behavioral and neural correlates of auditory feedback control of vocal production in patients with spinocerebellar ataxia (SCA) and healthy controls. All participants were instructed to produce sustained vowels while hearing their voice unexpectedly pitch-shifted -200 or -500 cents. The behavioral results revealed significantly larger vocal compensations for pitch perturbations in patients with SCA relative to healthy controls. At the cortical level, patients with SCA exhibited significantly smaller cortical P2 responses that were source localized in the right superior temporal gyrus, primary auditory cortex, and supramarginal gyrus than healthy controls. These findings indicate that reduced brain activity in the right temporal and parietal regions are significant neural contributors to abnormal auditory-motor processing of vocal pitch regulation as a consequence of cerebellar degeneration, which may be related to disrupted reciprocal interactions between the cerebellum and cortical regions that support the top-down modulation of auditory-vocal integration. These differences in behavior and cortical activity between healthy controls and patients with SCA demonstrate that the cerebellum is not only essential for feedforward control but also plays a crucial role in the feedback-based control of speech production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.