Evidence map›Paper›PMID 31365180›Full record

ArticleAnnals of clinical and translational neurology2019

Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia.

Elena Zapata-Arriaza, Fernando Mancha, Alejandro Bustamante, Francisco Moniche, Blanca Pardo-Galiana, Pilar Serrano-Gotarredona, Silvia Navarro-Herrero, Esther Pallisa, Julia Faura, Ángela Vega-Salvatierra and 6 more

Abstract read
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Elena Zapata-ArriazaStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.ORCID 0000-0002-1730-1999
Fernando ManchaStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Alejandro BustamanteNeurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain.
Francisco MonicheStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Blanca Pardo-GalianaStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Pilar Serrano-GotarredonaRadiology Department, University Hospital Virgen del Rocio, Seville, Spain.
Silvia Navarro-HerreroRadiology Department, University Hospital Virgen del Rocio, Seville, Spain.
Esther PallisaDepartment of Radiology, Vall d'Hebron University Hospital, Barcelona, Spain.
Julia FauraNeurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain.
Ángela Vega-SalvatierraStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Anna PenalbaNeurovascular Research Laboratory. Vall d'Hebron Institute of Research (VHIR), Universitat Autónoma de Barcelona, Barcelona, Spain.
Irene Escudero-MartínezStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Víctor Darío Ramos-HerreroStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.
Leire AzurmendiDepartment of Human Protein Sciences, University of Geneva, Geneve, Switzerland.
Jean Charles SanchezDepartment of Human Protein Sciences, University of Geneva, Geneve, Switzerland.
Joan MontanerStroke Research Program, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Seville, Spain.

Funding

Development, Implementation and AssessMent of Novel Training in Domain-based Competencies (DIAMOND)U01TR002013 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELLINGROD, VICKI L, JONES, CAROLYNN THOMAS · 2017 to 2019
$2.3M
Cooperative Cerebrovascular Disease Research Network (INVICTUS+) RD16/0019/0015Improving Translational Research Potential at the Institute of Biomedicine of Seville REGPOT-2013-1Instituto de Salud Carlos III JR16/0008ISCIII PI14/00971
6 · The paper itself

Abstract

To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.

Indexed as

AdrenomedullinAgedAged, 80 and overBiomarkersEarly DiagnosisFemaleHumansMalePeptide FragmentsPneumoniaPrognosisProtein PrecursorsReceptors, Urokinase Plasminogen ActivatorSerum Amyloid A ProteinStrokeAdrenomedullinBiomarkersmid-regional pro-adrenomedullin, humanPeptide FragmentsProtein PrecursorsReceptors, Urokinase Plasminogen ActivatorSerum Amyloid A Protein

Identifiers

PMID31365180
PMCPMC6764629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.