Evidence map›Paper›PMID 31365156›Full record

ArticlePaediatric and perinatal epidemiology2019

Risks of preterm birth among non-Hispanic black and non-Hispanic white women: Effect modification by maternal age.

Amaris M Keiser, Yasmmyn D Salinas, Andrew T DeWan, Nicola L Hawley, Pamela K Donohue, Donna M Strobino

Open access · greenAbstract read
In one paragraph

Article in Paediatric and perinatal epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Predictors of Inflammation-Mediated Preterm Birth.Physiology (Bethesda, Md.) · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Parental age and preterm birth: a population-based cohort of nearly 3 million California livebirths from 2007 to 2012.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  10. Review
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  12. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amaris M KeiserDivision of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8891-192X
Yasmmyn D SalinasDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Andrew T DeWanDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Nicola L HawleyDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Pamela K DonohueDivision of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Donna M StrobinoDepartment of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University · USYale University · US

Funding

RESEARCH IN PERINATAL MEDICINET32HD007094 · NICHD · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 1985 to 2015
$3.6M
NICHD NIH HHS T32 HD007094
6 · The paper itself

Abstract

backgroundPreterm birth (PTB) disproportionately affects African American compared with Caucasian women, although reasons for this disparity remain unclear. Some suggest that a differential effect of maternal age by race/ethnicity, especially at older maternal ages, may explain disparities.

objectiveTo determine whether the relationship between maternal age and preterm birth varies by race/ethnicity among primiparae non-Hispanic blacks (NHB) and non-Hispanic whites (NHW).

methodsA cross-sectional study of 367 081 singleton liveborn first births to NHB and NHW women in California from 2008 to 2012 was conducted. Rate ratios (RR) were estimated for PTB and its subtypes-spontaneous and clinician-initiated-after adjusting for confounders through Poisson regression. Universal age/race reference groups (NHW, 25-29 years) and race-specific reference groups (NHW or NHB, 25-29 years) were used for comparisons.

resultsAmong all women, RR of PTB was highest at the extremes of age (<15 and ≥40 years). Among NHBs, the risk of PTB was higher than among NHWs at all maternal ages (adjusted RR of PTB 1.38-2.93 vs 0.98-2.38). However, using race-specific reference groups, the risk of PTB for NHB women (RR 0.91-1.88) vs NHW women (RR 0.98-2.39) was nearly identical at all maternal ages, with overlapping confidence intervals. Analyses did not demonstrate substantial divergence of risk with advancing maternal age. PTB, spontaneous PTB, and clinician-initiated PTB demonstrated similar risk patterns at younger but not older maternal ages, where risk of clinician-initiated PTB increased sharply for all women.

conclusionsPrimiparae NHBs demonstrated increased risk of PTB, spontaneous PTB, and clinician-initiated PTB compared with NHWs at all maternal ages. However, RRs using race-specific reference groups converged across maternal ages, indicating a similar independent effect of maternal age on PTB by race/ethnicity. A differential effect of maternal age does not appear to explain disparities in preterm birth by race/ethnicity.

Indexed as

Black or African AmericanWhite PeopleAdolescentAdultCross-Sectional StudiesEducational StatusFemaleHumansInfant, NewbornMaternal AgeObesityPregnancyPremature BirthPrenatal CareReference StandardsRisk Factorsblackdisparitiesmaternal agepreterm birthweathering

Identifiers

PMID31365156
PMCPMC6993282
OpenAlexW2965350721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.