ArticleAlcoholism, clinical and experimental research2019
Associations Between Drinking and Cortical Thickness in Younger Adult Drinkers: Findings From the Human Connectome Project.
Article in Alcoholism, clinical and experimental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.Addiction biology · 2024Pooled it
- Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026Article
- Hippocampus-Ventral Striatum Connectivity Is Associated With Binge Drinking Frequency in Adults.Hippocampus · 2026Article
- Brain Structure and Substance Use: Disentangling Risk, Exposure, and Drug-Specific Effects.medRxiv : the preprint server for health sciences · 2026Article
- Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70 years old.BMC medicine · 2025Article
- The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review.Biomedicines · 2025Review
- Brain structural magnetic resonance imaging predictors of brief intervention response in individuals with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- Investigating the impact of sex and reproductive aging on latent signatures of modifiable dementia risk factors.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Exploring Causal Pathways to Sleep Quality in Young Adults Using a Multimodal Data-Driven Causal Discovery Analysis.Nature and science of sleep · 2025Article
- Differing Effects of Alcohol Use on Epigenetic and Brain Age in Adult Children of Parents with Alcohol Use Disorder.Brain sciences · 2024Article
- Sex differences in distributed error-related neural activation in problem-drinking young adults.Drug and alcohol dependence · 2024Article
- The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder.Addiction biology · 2024Article
- Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.Current addiction reports · 2024Article
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.Addiction biology · 2024Article
- To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.Neuropsychobiology · 2024Article
- Brain structural covariance network features are robust markers of early heavy alcohol use.Addiction (Abingdon, England) · 2024Article
- Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.medRxiv : the preprint server for health sciences · 2023Article
- Intracortical myelin in individuals with alcohol use disorder: An initial proof-of-concept study.Brain and behavior · 2022Article
- Alcohol's effects on the mouse brain are modulated by age and sex.Addiction biology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPrevious neuroimaging studies examining relations between alcohol misuse and cortical thickness have revealed that increased drinking quantity and alcohol-related problems are associated with thinner cortex. Although conflicting regional effects are often observed, associations are generally localized to frontal regions (e.g., dorsolateral prefrontal cortex [DLPFC], inferior frontal gyrus [IFG], and anterior cingulate cortex). Inconsistent findings may be attributed to methodological differences, modest sample sizes, and limited consideration of sex differences.
methodsThis study examined neuroanatomical correlates of drinking quantity and heavy episodic drinking in a large sample of younger adults (N = 706; M
resultsHierarchical linear regression models (controlling for age, sex, education, income, smoking, drug use, twin status, and intracranial volume) revealed significant inverse associations between drinks in past week and frequency of heavy drinking and cortical thickness in a majority of regions examined. The largest effect sizes were found for frontal regions (DLPFC, IFG, and the precentral gyrus). Follow-up regression models revealed that the left DLPFC was uniquely associated with both drinking variables. Sex differences were also observed, with significant effects largely specific to men.
conclusionsThis study adds to the understanding of brain correlates of alcohol use in a large, gender-balanced sample of younger adults. Although the cross-sectional methodology precludes causal inferences, these findings provide a foundation for rigorous hypothesis testing in future longitudinal investigations.
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