ArticleCerebral cortex (New York, N.Y. : 1991)2020
Cortical Structure and Cognition in Infants and Toddlers.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age.The American journal of clinical nutrition · 2022Trial
- Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.Translational psychiatry · 2026Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Brain Morphometry in Infants Later Diagnosed With Autism is Related to Later Language Skills.Human brain mapping · 2025Article
- Structural connectome gradients and their relationship to IQ in childhood.Frontiers in human neuroscience · 2025Article
- Left OFC Activation in Functional Near-Infrared Spectroscopy during an Inhibitory Control Task in an Early Years Sample: Integrating Stress Responses with Cognitive Function and Brain Activation.Developmental neuroscience · 2025Article
- Alterations in cortical thickness and volumes of subcortical structures in pediatric patients with complete spinal cord injury.CNS neuroscience & therapeutics · 2024Article
- Association of in utero HIV exposure with child brain structure and language development: a South African birth cohort study.BMC medicine · 2024Article
- Inferring neurocognition using artificial intelligence on brain MRIs.Frontiers in neuroimaging · 2024Review
- Structural brain correlates of non-verbal cognitive ability in 5-year-old children: Findings from the FinnBrain birth cohort study.Human brain mapping · 2023Article
- Multi-task Joint Prediction of Infant Cortical Morphological and Cognitive Development.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2023Article
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- Associations between digital media use and brain surface structural measures in preschool-aged children.Scientific reports · 2022Article
- Spherical Transformer on Cortical Surfaces.Machine learning in medical imaging. MLMI (Workshop) · 2022Article
- [Early detection of primary developmental language disorders-increasing relevance due to changes in diagnostic criteria?]Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2022Review
- Path Signature Neural Network of Cortical Features for Prediction of Infant Cognitive Scores.IEEE transactions on medical imaging · 2022Article
- Longitudinal association between maternal psychological stress during pregnancy and infant neurodevelopment: The moderating effects of responsive caregiving.Frontiers in pediatrics · 2022Article
- The maturation and cognitive relevance of structural brain network organization from early infancy to childhood.NeuroImage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Cortical structure has been consistently related to cognitive abilities in children and adults, yet we know little about how the cortex develops to support emergent cognition in infancy and toddlerhood when cortical thickness (CT) and surface area (SA) are maturing rapidly. In this report, we assessed how regional and global measures of CT and SA in a sample (N = 487) of healthy neonates, 1-year-olds, and 2-year-olds related to motor, language, visual reception, and general cognitive ability. We report novel findings that thicker cortices at ages 1 and 2 and larger SA at birth, age 1, and age 2 confer a cognitive advantage in infancy and toddlerhood. While several expected brain-cognition relationships were observed, overlapping cortical regions were also implicated across cognitive domains, suggesting that infancy marks a period of plasticity and refinement in cortical structure to support burgeoning motor, language, and cognitive abilities. CT may be a particularly important morphological indicator of ability, but its impact on cognition is relatively weak when compared with gestational age and maternal education. Findings suggest that prenatal and early postnatal cortical developments are important for cognition in infants and toddlers but should be considered in relation to other child and demographic factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.