ArticleAmerican journal of epidemiology2019
Metabolome-Wide Association Study of the Relationship Between Habitual Physical Activity and Plasma Metabolite Levels.
Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomic profiles of being physically active and less sedentary: a critical review.Metabolomics : Official journal of the Metabolomic Society · 2021Pooled it
- Association of Physical Activity With Bioactive Lipids and Cardiovascular Events.Circulation research · 2022Trial
- Metabolomics and cancer preventive behaviors in the BC Generations Project.Scientific reports · 2021Trial
- Leisure-time physical activity and metabolomic trajectories over the transition from late midlife to old age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Observational
- Lipidomic markers of habitual physical activity and risk of type 2 diabetes in American Indians.Scientific reports · 2025Article
- Prospective study of circulating metabolomic profiles and breast cancer incidence among predominantly premenopausal women.British journal of cancer · 2025Observational
- Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine.Addiction biology · 2025Article
- Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Physical activity, metabolites, and breast cancer associations.Journal of the National Cancer Institute · 2025Article
- Sample Preparation for Metabolomic Analysis in Exercise Physiology.Biomolecules · 2024Review
- Dietary and lifestyle insulinemic potentials, plasma metabolome, and risk of diverticulitis: a prospective cohort study.The American journal of clinical nutrition · 2024Article
- Lipidomics and metabolomics as potential biomarkers for breast cancer progression.npj metabolic health and disease · 2024Review
- Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies.Med (New York, N.Y.) · 2024Article
- Metabolite Signature of Life's Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans.Circulation. Genomic and precision medicine · 2023Article
- Metabolomics to Understand Alterations Induced by Physical Activity during Pregnancy.Metabolites · 2023Review
- Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults.Nutrition & metabolism · 2023Article
- Metabolome-wide association study on physical activity.Scientific reports · 2023Article
- Metabolomic profiles associated with physical activity in White and African American adult men.PloS one · 2023Article
- Prediagnostic Plasma Metabolomics and the Risk of Exfoliation Glaucoma.Investigative ophthalmology & visual science · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
We identified plasma metabolites associated with habitual physical activity among 5,197 US participants from the Nurses' Health Study (NHS), Nurses' Health Study II (NHS II), and the Health Professionals Follow-up Study (HPFS). Physical activity was assessed every 2-4 years via self-report questionnaires. Blood was collected in the NHS in 1989-1990, in NHS II during 1996-1999, and in the HPFS during 1993-1995. Metabolic profiling was conducted by liquid chromatography-mass spectrometry. Our study included 337 known metabolites, with 256 of them classified as lipids. We corrected for multiple testing by controlling the tail probability of the proportion of false positives (TPPFP) and accounted for correlated tests using bootstrapping. Physical activity was significantly associated with 20 metabolites after correction for multiple testing (TPPFP < 0.05), and positive associations were found for most of the metabolites, including 2 amino acids (citrulline and glycine), 4 cholesteryl esters (C18:2, C18:1, C16:0, C18:3), 8 phosphocholines (PCs) (C36:4 PC-A, C34:3 PC plasmalogen, C36:3 PC plasmalogen, C34:2 PC plasmalogen, C36:2 PC) and lysophosphatidylcholines (C18:2, C20:5, C18:1), and 3 phosphatidylethanolamines (PEs) (C38:3 PE plasmalogen) and lysophosphatidylethanolamines (C18:2, C18:1). We independently replicated the 20 metabolites among 2,305 women in the Women's Health Initiative using 1993 data, and half of the metabolites were replicated. Our study may help identify biomarkers of physical activity and provide insight into biological mechanisms underlying the beneficial effect of being physically active on cardiometabolic health.
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