Evidence map›Paper›PMID 31364549›Full record

ArticleEpidemiology and infection2019

Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections.

N Komadina, S G Sullivan, K Kedzierska, S M Quiñones-Parra, K Leder, J McVernon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epidemiology and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Occupational exposure to influenza virus of the wild birds].Revista espanola de salud publica · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

N KomadinaWHO Collaborating Centre for Reference and Research on Influenza,Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity,Victoria,3000,Australia; andSchool of Public Health and Preventive Medicine,Monash University,553 St Kilda Road,Melbourne,Australia.ORCID 0000-0002-8751-5730
S G SullivanWHO Collaborating Centre for Reference and Research on Influenza,Royal Melbourne Hospital and the Doherty Department,University of Melbourne at the Peter Doherty Institute for Infection and Immunity,Victoria,3000,Australia; andMelbourne School of Population and Global Health,The University of Melbourne,Melbourne,3000,Australia.
K KedzierskaDepartment of Microbiology & Immunology,University of Melbourne at the Peter Doherty Institute for Infection & Immunity,Victoria,3000,Australia.
S M Quiñones-ParraDepartment of Molecular Biology,University of California,San Diego,California,USA.
K LederSchool of Public Health and Preventive Medicine,Monash University,553 St Kilda Road,Melbourne,Australia; andVictorian Infectious Disease Service,Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity,Victoria,3000,Australia.
J McVernonVictorian Infectious Diseases Reference Laboratory Epidemiology Unit, Royal Melbourne Hospital and the Doherty Department,University of Melbourne at the Peter Doherty Institute for Infection and Immunity,Victoria,3000,Australia;Melbourne School of Population and Global Health,The University of Melbourne,Melbourne,3000,Australiaandthe Murdoch Children's Research Institute,Melbourne,3000,Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear.

Indexed as

Age DistributionEnvironmental ExposureAntigens, ViralChinaDisease SusceptibilityFemaleHumansIncidenceInfluenza A Virus, H5N1 SubtypeInfluenza A Virus, H7N9 SubtypeInfluenza, HumanMalePeptidesAntigens, ViralPeptidesAvian fluH5N1H7N9immunogenic peptidesinfluenza A

Identifiers

PMID31364549
PMCPMC6624876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.