ArticleStress (Amsterdam, Netherlands)2020
Executive Control, Cytokine Reactivity to Social Stress, and Depressive Symptoms: Testing the Social Signal Transduction Theory of Depression.
Article in Stress (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Inflammation as a mediating pathway between social defeat and mental health in humans: A systematic review.Translational psychiatry · 2026Pooled it
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.Brain, behavior, and immunity · 2020Pooled it
- Oxytocin, cortisol, and cognitive control during acute and naturalistic stress.Stress (Amsterdam, Netherlands) · 2021Trial
- Lifetime stressor exposure, executive functioning, and internalizing symptoms during emerging adulthood.Scientific reports · 2026Article
- The inflammation-depression link: How social networks buffer or exacerbate risk.Brain, behavior, & immunity - health · 2025Article
- Adverse childhood experiences, inflammation, and depression: evidence of sex- and stressor specific effects in a nationally representative longitudinal sample of U.S. adolescents.Psychological medicine · 2025Article
- Advancing Antidepressive Agents: Drug Discovery and Polymer-Based Drug Delivery Systems for Improved Treatment Outcome.Biomedicines · 2025Review
- Lifetime adversity predicts depression, anxiety, and cognitive impairment in a nationally representative sample of older adults in the United States.Journal of clinical psychology · 2024Article
- Understanding the combined effects of sleep deprivation and acute social stress on cognitive performance using a comprehensive approach.Brain, behavior, & immunity - health · 2023Article
- The Insidious Influence of Stress: An Integrated Model of Stress, Executive Control, and Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Activation Versus Change as a Principle Underlying Intervention Strategies to Promote Health Behaviors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Review
- Interplay Between the Immune and Nervous Cognitive Systems in Homeostasis and in Malaria.International journal of biological sciences · 2023Review
- A Review of Psychological Stress among Students and Its Assessment Using Salivary Biomarkers.Behavioral sciences (Basel, Switzerland) · 2022Review
- The Role of Social Position Within Peer Groups in Distress-Motivated Smoking Among Adolescents.Journal of studies on alcohol and drugs · 2022Article
- Consequences of pandemic-associated social restrictions: Role of social support and the oxytocin system.Psychoneuroendocrinology · 2022Review
- Increased inflammation predicts nine-year change in major depressive disorder diagnostic status.Journal of abnormal psychology · 2021Article
- Psychobiology of Stress and Adolescent Depression (PSY SAD) Study: Protocol overview for an fMRI-based multi-method investigation.Brain, behavior, & immunity - health · 2021Article
- What moderates salivary markers of inflammation reactivity to stress? A descriptive report and meta-regression.Stress (Amsterdam, Netherlands) · 2021Article
- Mental health during the COVID-19 pandemic and beyond: The importance of the vagus nerve for biopsychosocial resilience.Neuroscience and biobehavioral reviews · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Social Signal Transduction Theory of Depression hypothesizes that social stress upregulates inflammatory activity, which in turn contributes to depression for some individuals. However, the specific cognitive processes underlying social stress-induced increases in inflammatory activity remain unclear. We addressed this issue by examining two separate relations: (1) between executive control measured following a laboratory-based social stress induction and individuals' pro-inflammatory cytokine responses to the same stress induction and (2) between pro-inflammatory cytokine responses and participants' depressive symptom levels. Healthy young participants (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.