Evidence map›Paper›PMID 31363910›Full record

ReviewHepatology international2019

Reversal of NASH fibrosis with pharmacotherapy.

Joseph J Alukal, Paul J Thuluvath

Abstract readReview
PubMed Publisher
In one paragraph

Review in Hepatology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Emerging nanomedicine for liver diseases treatment.Journal of nanobiotechnology · 2025
    Review
  2. Review
  3. Growth hormone and nonalcoholic fatty liver disease.Immunometabolism (Cobham, Surrey) · 2023 · on this map
    Review
  4. Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2023
    Review
  5. New Drugs for Hepatic Fibrosis.Frontiers in pharmacology · 2022
    Review
  6. Therapeutic potentials of fasudil in liver fibrosis.World journal of gastroenterology · 2021
    Article
  7. MR Elastography of the Abdomen: Basic Concepts.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  8. MR Elastography of the Abdomen: Experimental Protocols.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph J AlukalInstitute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, 21202, USA.
Paul J ThuluvathInstitute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, 21202, USA. thuluvath@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epidemiology, pathogenesis and its progression to cirrhosis has improved over the last 2 decades. Currently, however, there are no FDA-approved treatment options for fibrosis resulting from NAFLD. A number of compounds targeting multiple pathways involved in the progression of NAFLD are currently in phase 2-3 trials. In this review, we will briefly discuss the epidemiology, the pathogenesis and the current status of treatment of NAFLD.

Indexed as

BenzamidesChalconesChenodeoxycholic AcidDisease ProgressionHumansImidazolesLiverLiver CirrhosisNon-alcoholic Fatty Liver DiseasePropionatesPyridinesRisk FactorsSulfoxides2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxo-1-propenyl)phenoxyl)-2-methylpropanoic acidBenzamidescenicrivirocChalconesChenodeoxycholic AcidImidazolesobeticholic acidPropionatesPyridinesselonsertibSulfoxidesAntifibrotic agentsNAFLDNASH

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.