ReviewPediatric nephrology (Berlin, Germany)2020
Clinical impact of tissue sodium storage.
Review in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Open-label randomized controlled study of salt-restrictedWorld journal of methodology · 2026Trial
- Effects of dapagliflozin on sodium excretion, blood pressure and volume status in patients with type 2 diabetes and/or chronic kidney disease: The DAPASALT trial.Diabetes, obesity & metabolism · 2025Trial
- Letter to the Editor: Revisiting salt restriction in hyponatremic cirrhosis - a paradigm in need of refinement?World journal of methodology · 2026Article
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
- The role of the mineralocorticoid receptor in skin.Molecular and cellular endocrinology · 2025Review
- Noninvasive assessment of volume status in patients with end-stage kidney disease using a wearable monitor and cutaneous hydration sensor.BMC nephrology · 2025Article
- Dietary salt in liver cirrhosis: With a pinch of salt!World journal of hepatology · 2023Review
- The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps.NPJ microgravity · 2023Review
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
- Importance of Micromilieu for Pathophysiologic Mineralocorticoid Receptor Activity-When the Mineralocorticoid Receptor Resides in the Wrong Neighborhood.International journal of molecular sciences · 2022Review
- Proline Transport and Growth Changes in Proline Transport Mutants ofMicroorganisms · 2022Article
- Mosaic theory revised: inflammation and salt play central roles in arterial hypertension.Cellular & molecular immunology · 2022Review
- Does Excess Tissue Sodium Storage Regulate Blood Pressure?Current hypertension reports · 2022Review
- Sodium First Approach, to Reset Our Mind for Improving Management of Sodium, Water, Volume and Pressure in Hemodialysis Patients, and to Reduce Cardiovascular Burden and Improve Outcomes.Frontiers in nephrology · 2022Review
- Pathophysiology and genetics of salt-sensitive hypertension.Frontiers in physiology · 2022Review
- From salt to hypertension, what is missed?Journal of clinical hypertension (Greenwich, Conn.) · 2021Review
- Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus.JCI insight · 2021Article
- Edelman Revisited: Concepts, Achievements, and Challenges.Frontiers in medicine · 2021Review
- Sodium-induced inflammation-an invisible player in resistant hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Body Fluid-Independent Effects of Dietary Salt Consumption in Chronic Kidney Disease.Nutrients · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In recent times, the traditional nephrocentric, two-compartment model of body sodium has been challenged by long-term sodium balance studies and experimental work on the dermal interstitium and endothelial surface layer. In the new paradigm, sodium can be stored without commensurate water retention in the interstitium and endothelial surface layer, forming a dynamic third compartment for sodium. This has important implications for sodium homeostasis, osmoregulation and the hemodynamic response to salt intake. Sodium storage in the skin and endothelial surface layer may function as a buffer during periods of dietary depletion and excess, representing an extra-renal mechanism regulating body sodium and water. Interstitial sodium storage may also serve as a biomarker for sodium sensitivity and cardiovascular risk, as well as a target for hypertension treatment. Furthermore, sodium storage may explain the limitations of traditional techniques used to quantify sodium intake and determine infusion strategies for dysnatraemias. This review is aimed at outlining these new insights into sodium homeostasis, exploring their implications for clinical practice and potential areas for further research for paediatric and adult populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.