ArticleOpen forum infectious diseases2019
Radiological Signs of Latent Tuberculosis on Chest Radiography: A Systematic Review and Meta-Analysis.
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A rare case report of acute respiratory distress syndrome secondary to pulmonary tuberculosis: Review of radiographic findings of pulmonary tuberculosis to enhance diagnosis accuracy.Respiratory medicine case reports · 2026Article
- Association of inactive pulmonary tuberculosis lesions with the risk of active disease development in the elderly: a population-based retrospective study.ERJ open research · 2025Article
- A scoring model based on the pleural effusion adenosine deaminase-to-serum C-reactive protein ratio for differentiating tuberculous pleural effusion from non-tuberculous benign pleural effusion.BMC pulmonary medicine · 2025Article
- Role of interferon-gamma release assay for screening and monitoring of latent tuberculosis infection in kidney transplant recipients.BMC infectious diseases · 2024Article
- Latent Tuberculosis Infection in Healthcare Workers: A Cross-Sectional Study from a Tertiary Hospital in Central Anatolia.Journal of clinical practice and research · 2024Article
- Development and validation of a risk prediction model for pulmonary tuberculosis among presumptive tuberculosis cases in Ethiopia.BMJ open · 2023Article
- Chest Radiography of Tuberculosis: Determination of Activity Using Deep Learning Algorithm.Tuberculosis and respiratory diseases · 2023Article
- Alternative biomarkers of tuberculosis infection in patients with immune-mediated inflammatory diseases.Frontiers in medicine · 2023Article
- The Diagnostic Deceiver: Radiological Pictorial Review of Tuberculosis.Diagnostics (Basel, Switzerland) · 2022Review
- The burden and predictors of latent tuberculosis infection among elder adults in high epidemic rural area of tuberculosis in Zhejiang, China.Frontiers in cellular and infection microbiology · 2022Article
- Correlation between tuberculosis-specific interferon-γ release assay and intrathoracic calcification: A cross-sectional study.PloS one · 2022Article
- Acute miliary tuberculosis in pregnancy after in vitro fertilization and embryo transfer: a report of seven cases.BMC infectious diseases · 2021Article
- Impact of Positive Interferon-Gamma Release Assay on IVF-ET Pregnancy Outcomes in Infertile Patients With Untreated Prior Tuberculosis: A Prospective Cohort Study.Frontiers in medicine · 2021Article
- Trends in diagnostic methods and treatment of latent tuberculosis infection in a tertiary care center from 2000 to 2017.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Observational
- Miliary Tuberculosis during R-MPV Therapy in an Elderly Patient with Primary Central Nerve System Lymphoma: A Case Report.Case reports in oncologyArticle
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveCurrent guidelines recommend screening for latent tuberculosis infection (LTBI) with a tuberculin skin test (TST) or interferon gamma release assay (IGRA), or both. Many also recommend chest radiography (CXR), although its added value is uncertain. This systematic review assessed the prevalence of abnormalities suggestive of LTBI on CXR (LTBI-CXR lesions) and evaluated the strength of the association.
methodWe searched 4 databases up to September 2017 and systematically reviewed cross-sectional and cohort studies reporting LTBI-CXR lesions in individuals with a positive TST or IGRA, or both, result. Prevalence estimates were pooled using random effects models and odds ratios (ORs) were used to calculate risk estimates.
resultsIn the 26 included studies, the pooled proportion of individuals with LTBI having LTBI-CXR lesions was 0.15 (95% confidence interval [CI], 0.12-0.18]. In 16 studies that reported on individuals with LTBI and uninfected controls, LTBI-CXR lesions were associated with a positive TST result ≥ 5 mm or ≥ 10 mm (OR, 2.45; 95% CI, 1.00-5.99; and OR, 2.06; 95% CI, 1.38-3.09, respectively) and with a positive QuantiFERON result (OR, 1.99; 95% CI, 1.17-3.39) compared to CXR in uninfected controls. Although few studies reported specified lesions, calcified nodules were most frequently reported in individuals with LTBI (proportion, 0.07; 95% CI, 0.02-0.11).
conclusionsLesions on CXR suggestive of previous infection with Mycobacterium tuberculosis were significantly associated with positive tests for LTBI, although the sensitivity was only 15%. This finding may have added value when detection of past LTBI is important but immunodiagnostic tests may be unreliable.
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