ArticleNucleic acids research2019
KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
Article in Nucleic acids research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- KDM2B controls HIF levels and activity through its JmjC and CxxC domains.The Biochemical journal · 2026Article
- Variants in the CxxC domain of the epigenetic regulator KDM2B support its role in developmental eye anomalies.European journal of human genetics : EJHG · 2026Article
- Preventing CpG hypermethylation in oocytes safeguards mouse development.Developmental cell · 2025Article
- Air pollution modulates brown adipose tissue function through epigenetic regulation by HDAC9 and KDM2B.JCI insight · 2025Article
- The histone H3 lysine 36 demethylase KDM2A/FBXL11 controls Polycomb-mediated gene repression and germ cell development in male mice.Nature communications · 2025Article
- Review
- Creation of knockin mice for the fluorescence protein based in vivo identification of skeletal myofiber types.Scientific reports · 2025Article
- The PNUTS phosphatase complex controls transcription pause release.Molecular cell · 2024Article
- Mechanisms and cross-talk of regulated cell death and their epigenetic modifications in tumor progression.Molecular cancer · 2024Review
- Regulatory and evolutionary impact of DNA methylation in two songbird species and their naturally occurring FBMC biology · 2024Article
- The Effects of Larval Cryopreservation on the Epigenetics of the Pacific OysterInternational journal of molecular sciences · 2023Article
- KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.Nature communications · 2023Article
- A CpG island-encoded mechanism protects genes from premature transcription termination.Nature communications · 2023Article
- The histone code of the fungal genusMicrobial genomics · 2022Article
- JmjC Family of Histone Demethylases Form Nuclear Condensates.International journal of molecular sciences · 2022Article
- Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors.iScience · 2022Article
- PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency.Nature structural & molecular biology · 2021Article
- Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness.Nature genetics · 2021Article
- BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome.Genes & development · 2021Article
- Functions of Polycomb Proteins on Active Targets.Epigenomes · 2020Review
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Authors and funding
7 authors.
Funding
Abstract
CpG islands (CGIs) are associated with the majority of mammalian gene promoters and function to recruit chromatin modifying enzymes. It has therefore been proposed that CGIs regulate gene expression through chromatin-based mechanisms, however in most cases this has not been directly tested. Here, we reveal that the histone H3 lysine 36 (H3K36) demethylase activity of the CGI-binding KDM2 proteins contributes only modestly to the H3K36me2-depleted state at CGI-associated gene promoters and is dispensable for normal gene expression. Instead, we discover that KDM2 proteins play a widespread and demethylase-independent role in constraining gene expression from CGI-associated gene promoters. We further show that KDM2 proteins shape RNA Polymerase II occupancy but not chromatin accessibility at CGI-associated promoters. Together this reveals a demethylase-independent role for KDM2 proteins in transcriptional repression and uncovers a new function for CGIs in constraining gene expression.
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