ArticleWorld journal of transplantation2019
Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis.
Article in World journal of transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Proton pump inhibitor use after kidney transplantation and graft outcomes: A matched national cohort study.Medicine · 2026Article
- Effect of Tegoprazan on Tacrolimus and Mycophenolate Levels in Kidney Transplant Recipients: A Randomized Controlled Study Using a Smart Trial Platform.Pharmaceuticals (Basel, Switzerland) · 2025Article
- COVID-19 among kidney transplant recipients: evaluating risk factors during the initial phase of the pandemic.Clinical kidney journal · 2025Article
- Proton Pump Inhibitors Use in Kidney Transplant Recipients: A Population-Based Study.Canadian journal of kidney health and disease · 2024Article
- Incidence, Pathogenesis, and Management of Proton Pump Inhibitor-Induced Nephrotoxicity.Drug safety · 2022Review
- Recent Advances and Clinical Outcomes of Kidney Transplantation.Journal of clinical medicine · 2020Article
- The Effect of Proton Pump Inhibitor Use on Renal Function in Kidney Transplanted Patients.Journal of clinical medicine · 2020Article
- Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients.Journal of clinical medicine · 2019Article
- Long-term Effects of Gastric Acid Prophylaxis in Kidney Transplant Recipients.Revista de nefrologia, dialisis y transplante : publicacion conjunta de la Asociacion Regional de Dialisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires y la Sociedad Argentina de NefrologiaArticle
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adverse renal effects of proton pump inhibitors (PPIs) are increasingly recognized in both the general population and patients with chronic kidney disease. Several pharmacokinetic studies have also raised concerns regarding the interaction between PPIs and immunosuppressive drugs in transplant patients. Whether the adverse effects of PPIs have a clinical significance in kidney transplant recipients remains unclear. We performed this meta-analysis to assess the risk of adverse effects in kidney transplant recipients on PPI compared with those without PPI exposure.
aimTo investigate the risk of acute rejection, graft loss, hypomagnesemia, renal dysfunction, and overall mortality in kidney transplant recipients on PPI compared with those without PPI exposure.
methodsA systematic review was conducted in MEDLINE, EMBASE, and Cochrane databases from inception through October 2018 to identify studies that evaluated the adverse effects of PPIs in kidney transplant recipients, including biopsy-proven acute rejection, graft loss, hypomagnesemia, renal function, and overall mortality. Effect estimates from the individual studies were extracted and combined using random-effect, generic inverse variance method of DerSimonian and Laird. The protocol for this meta-analysis is registered with PROSPERO, No. CRD42018115676.
resultsFourteen observational studies with 6786 kidney transplant recipients were enrolled. No significant association was found between PPI exposure and the risk of biopsy-proven acute rejection at ≥ 1 year [pooled odds ratio (OR), 1.25; 95% confidence interval (CI), 0.82-1.91,
conclusionPPI use was not associated with significant risks of higher acute rejection, graft loss, or 1-year mortality. However, the risk of hypomagnesemia was significantly increased with PPI use. Thus, future studies are needed to assess the impact of PPIs on long-term outcomes.
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