ArticleClinical reviews in bone and mineral metabolism2018
Systemic Bone Loss After Fracture.
Article in Clinical reviews in bone and mineral metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Beyond the initial impact: a systematic review of post-traumatic bone loss and its mechanisms.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Romosozumab in patients who experienced an on-study fracture: post hoc analyses of the FRAME and ARCH phase 3 trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Trial
- Towards High-Accuracy Athletic Injury Predictions Using a First-Principles Modelling Approach: Theory to (Future) Practice.Sports medicine (Auckland, N.Z.) · 2026Review
- Developing a Fundamental Theoretical Definition for Athletic Injury: Metaphysics, Logic, and Mathematics.Sports medicine (Auckland, N.Z.) · 2026Review
- Differences in lumbar spine bone mineral density measured by quantitative computed tomography and dual-energy X-ray absorptiometry: an age- and sex-specific analysis.Journal of orthopaedic surgery and research · 2026Article
- Article
- Nonlinear Association of Estimated Pulse Wave Velocity With Bone Health Outcomes: Evidence From the NHANES Database.International journal of endocrinology · 2026Article
- Brick by Brick the Wall Is Being Built: Particle-Based Scaffolds for Regenerative Medicine.Polymers · 2025Review
- Investigating the role of complement 5a in systemic bone loss after myocardial infarction.Bone · 2025Article
- The Interplay of Angiogenesis and Osteogenesis in Non-Stabilized Incomplete Tibial Fractures: A Temporal Study in Rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Role of Body Fat and Metabolic Rate in Site-Specific Fracture Risk: A 20-Year Taiwanese Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Risk of fragility fracture is aggravated during bone regeneration processes in osteoporotic sheep.PloS one · 2025Article
- Review
- Sticky Bone as a New Type of Autologous Bone Grafting in Schatzker Type II Tibial Plateau Fracture Case Report.Life (Basel, Switzerland) · 2024Article
- Comparison of the efficacy and safety of vertebroplasty with different pedicle approaches for osteoporotic vertebral.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Review
- The heart-bone connection: relationships between myocardial infarction and osteoporotic fracture.American journal of physiology. Heart and circulatory physiology · 2024Review
- Pathophysiological mechanism of acute bone loss after fracture.Journal of advanced research · 2023Review
- Progress in Prevention and Treatment of Acute Bone Loss in Orthopedics.International journal of endocrinology · 2023Review
- Development of Osteopenia During Distal Radius Fracture Recovery.Journal of hand surgery global online · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A history of prior fracture is the most reliable indicator of prospective fracture risk. Increased fracture risk is not confined to the region of the prior fracture, but is operant at all skeletal sites, providing strong evidence of systemic bone loss after fracture. Animal and human studies suggest that systemic bone loss begins shortly after fracture and persists for several years in humans. In fact, bone quantity and bone quality may never fully return to their pre-fracture levels, especially in older subjects, demonstrating a need for improved understanding of the mechanisms leading to systemic bone loss after fracture in order to reduce subsequent fracture risk. Although the process remains incompletely understood, mechanical unloading (disuse), systemic inflammation, and hormones that control calcium homeostasis may all contribute to systemic bone loss. Additionally, individual factors can potentially affect the magnitude and time course of systemic bone loss and recovery. The magnitude of systemic bone loss correlates positively with injury severity and age. Men may also experience greater bone loss or less recovery than women after fracture. This review details the current understanding of systemic bone loss following fracture, including possible underlying mechanisms and individual factors that may affect this injury response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.