ArticleScientific reports2019
A Prototype Antibody-based Biosensor for Measurement of Salivary MMP-8 in Periodontitis using Surface Acoustic Wave Technology.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Mechanistic Characterization of Biologically Inspired Oral Neutrophil Isolation for AI-Assisted Oral Inflammatory Load Assessment.Biomimetics (Basel, Switzerland) · 2026Article
- Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8).Biosensors · 2026Article
- Performance Validation of Fabricated Nanomaterial-Based Biosensor for Matrix Metalloproteinase-8 Protein Detection.European journal of dentistry · 2026Article
- Electrochemical and optical biosensors for periodontitis detection.Biochemistry and biophysics reports · 2026Review
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Salivary Biomarker Analysis to Distinguish Between Health and Periodontitis Status: A Preliminary Study.Dentistry journal · 2025Article
- Effect of the underlayer on the elastic parameters of the CoFeB/MgO heterostructures.Scientific reports · 2024Article
- Point-of-care diagnostic devices for periodontitis - current trends and urgent need.Sensors & diagnostics · 2024Review
- Diagnostic performance of a point-of-care test device for periodontitis using human saliva: a single-center, single-blinded, confirmatory study.Clinical oral investigations · 2023Article
- Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation.International journal of oral science · 2023Review
- Application of Shear Horizontal Surface Acoustic Wave (SH-SAW) Immunosensor in Point-of-Care Diagnosis.Biosensors · 2023Review
- Review
- Measurements of Anti-SARS-CoV-2 Antibody Levels after Vaccination Using a SH-SAW Biosensor.Biosensors · 2022Article
- Ability of matrix metalloproteinase-8 biosensor, IFMA, and ELISA immunoassays to differentiate between periodontal health, gingivitis, and periodontitis.Journal of periodontal research · 2022Article
- Graphene-Based Biosensors for Molecular Chronic Inflammatory Disease Biomarker Detection.Biosensors · 2022Review
- Enzymatic Methods for Salivary Biomarkers Detection: Overview and Current Challenges.Molecules (Basel, Switzerland) · 2021Review
- Validation and verification of predictive salivary biomarkers for oral health.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is an economically important disease which is highly prevalent worldwide. Current diagnostic approaches are time-consuming and require interpretation of multiple aspects of clinical and radiographic assessment. Chair-side monitoring of inflammatory mediators of periodontitis could provide immediate information about disease activity, which can inform patient management. We aimed to develop a novel prototype biosensor to measure salivary matrix metalloproteinase-8 (MMP-8) using specific antibodies and surface acoustic wave (SAW) technology. The analytical performance of the prototype biosensor was compared to standard enzyme-linked immunosorbent assay (ELISA) using unstimulated saliva samples obtained from patients with periodontitis before and after non-surgical treatment (N = 58), patients with gingivitis (N = 54) and periodontally healthy volunteers (N = 65). Receiver operator characteristic (ROC) analysis for distinguishing periodontitis from health revealed an almost identical performance between the sensor and ELISA assays (area under curve values (AUC): ELISA 0.93; SAW 0.89). Furthermore, both analytical approaches yielded readouts which distinguished between heath, gingivitis and periodontitis, correlated identically with clinical measures of periodontal disease and recorded similar post-treatment decreases in salivary MMP-8 in periodontitis. The assay time for our prototype device is 20 minutes. The prototype SAW biosensor is a novel and rapid method of monitoring periodontitis which delivers similar analytical performance to conventional laboratory assays.
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